node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BBOX1 | FSD1 | ENSP00000263182 | ENSP00000221856 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family. | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | 0.548 |
BCL7A | FSD1 | ENSP00000445868 | ENSP00000221856 | B-cell CLL/lymphoma 7 protein family member A; BAF chromatin remodeling complex subunit BCL7A. | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | 0.513 |
CDK5 | FSD1 | ENSP00000419782 | ENSP00000221856 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neu [...] | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | 0.467 |
FN1 | FSD1 | ENSP00000346839 | ENSP00000221856 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts. | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | 0.497 |
FSD1 | BBOX1 | ENSP00000221856 | ENSP00000263182 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family. | 0.548 |
FSD1 | BCL7A | ENSP00000221856 | ENSP00000445868 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | B-cell CLL/lymphoma 7 protein family member A; BAF chromatin remodeling complex subunit BCL7A. | 0.513 |
FSD1 | CDK5 | ENSP00000221856 | ENSP00000419782 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neu [...] | 0.467 |
FSD1 | FN1 | ENSP00000221856 | ENSP00000346839 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts. | 0.497 |
FSD1 | FSTL3 | ENSP00000221856 | ENSP00000166139 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | Follistatin-related protein 3; Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow st [...] | 0.468 |
FSD1 | JAKMIP2 | ENSP00000221856 | ENSP00000479248 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family. | 0.521 |
FSD1 | MARK1 | ENSP00000221856 | ENSP00000483424 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | Serine/threonine-protein kinase MARK1; Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DC [...] | 0.463 |
FSD1 | SCRN1 | ENSP00000221856 | ENSP00000388942 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | Secernin-1; Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity). | 0.531 |
FSD1 | TUBG1 | ENSP00000221856 | ENSP00000251413 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | Tubulin gamma-1 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation. | 0.551 |
FSD1 | UBFD1 | ENSP00000221856 | ENSP00000379217 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | Ubiquitin domain-containing protein UBFD1; May play a role as NF-kappa-B regulator. | 0.474 |
FSTL3 | FSD1 | ENSP00000166139 | ENSP00000221856 | Follistatin-related protein 3; Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow st [...] | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | 0.468 |
JAKMIP2 | FSD1 | ENSP00000479248 | ENSP00000221856 | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family. | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | 0.521 |
MARK1 | FSD1 | ENSP00000483424 | ENSP00000221856 | Serine/threonine-protein kinase MARK1; Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DC [...] | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | 0.463 |
SCRN1 | FSD1 | ENSP00000388942 | ENSP00000221856 | Secernin-1; Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity). | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | 0.531 |
TUBG1 | FSD1 | ENSP00000251413 | ENSP00000221856 | Tubulin gamma-1 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation. | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | 0.551 |
UBFD1 | FSD1 | ENSP00000379217 | ENSP00000221856 | Ubiquitin domain-containing protein UBFD1; May play a role as NF-kappa-B regulator. | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | 0.474 |