ADP-ribosylation factor-like protein 2-binding protein; Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.

Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.

Arpin; Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.

Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.

Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family.

Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.

B-cell CLL/lymphoma 7 protein family member A; BAF chromatin remodeling complex subunit BCL7A.

Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.

Glutathione-specific gamma-glutamylcyclotransferase 2; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.

Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...]

Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.

EF-hand domain-containing protein D1; Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production. May play a role in neuronal differentiation (By similarity).

Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.

Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.

ADP-ribosylation factor-like protein 2-binding protein; Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.

Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.

Arpin; Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.

Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.

Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family.

Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.

B-cell CLL/lymphoma 7 protein family member A; BAF chromatin remodeling complex subunit BCL7A.

Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.

Glutathione-specific gamma-glutamylcyclotransferase 2; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.

Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...]

Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.

EF-hand domain-containing protein D1; Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production. May play a role in neuronal differentiation (By similarity).

Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.

E3 ubiquitin-protein ligase MIB1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits p [...]

Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.

Ubiquitin domain-containing protein UBFD1; May play a role as NF-kappa-B regulator.

Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.

Ubiquitin-like domain-containing CTD phosphatase 1; Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.

E3 ubiquitin-protein ligase MIB1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits p [...]

Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.

Ubiquitin domain-containing protein UBFD1; May play a role as NF-kappa-B regulator.

Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.

Ubiquitin domain-containing protein UBFD1; May play a role as NF-kappa-B regulator.

Ubiquitin-like domain-containing CTD phosphatase 1; Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.