node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C10orf71 | SIPA1L3 | ENSP00000363259 | ENSP00000222345 | Cardiac-enriched FHL2-interacting protein; Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. | Signal-induced proliferation-associated 1-like protein 3; Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens. | 0.524 |
LZTS2 | SIPA1L1 | ENSP00000359240 | ENSP00000450832 | Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. Belongs to the LZTS2 family. | Signal-induced proliferation-associated 1-like protein 1; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). | 0.885 |
LZTS2 | SIPA1L2 | ENSP00000359240 | ENSP00000355589 | Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. Belongs to the LZTS2 family. | Signal-induced proliferation-associated 1-like protein 2; Signal induced proliferation associated 1 like 2. | 0.634 |
LZTS2 | SIPA1L3 | ENSP00000359240 | ENSP00000222345 | Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. Belongs to the LZTS2 family. | Signal-induced proliferation-associated 1-like protein 3; Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens. | 0.637 |
LZTS3 | SIPA1L1 | ENSP00000353496 | ENSP00000450832 | Leucine zipper putative tumor suppressor 3; May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses; Belongs to the LZTS3 family. | Signal-induced proliferation-associated 1-like protein 1; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). | 0.950 |
LZTS3 | SIPA1L2 | ENSP00000353496 | ENSP00000355589 | Leucine zipper putative tumor suppressor 3; May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses; Belongs to the LZTS3 family. | Signal-induced proliferation-associated 1-like protein 2; Signal induced proliferation associated 1 like 2. | 0.610 |
LZTS3 | SIPA1L3 | ENSP00000353496 | ENSP00000222345 | Leucine zipper putative tumor suppressor 3; May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses; Belongs to the LZTS3 family. | Signal-induced proliferation-associated 1-like protein 3; Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens. | 0.718 |
PGBD1 | SIPA1L3 | ENSP00000259883 | ENSP00000222345 | piggyBac transposable element derived 1. | Signal-induced proliferation-associated 1-like protein 3; Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens. | 0.466 |
SIPA1 | SIPA1L2 | ENSP00000377771 | ENSP00000355589 | Signal-induced proliferation-associated protein 1; GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression (By similarity). | Signal-induced proliferation-associated 1-like protein 2; Signal induced proliferation associated 1 like 2. | 0.659 |
SIPA1 | SIPA1L3 | ENSP00000377771 | ENSP00000222345 | Signal-induced proliferation-associated protein 1; GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression (By similarity). | Signal-induced proliferation-associated 1-like protein 3; Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens. | 0.642 |
SIPA1 | YWHAZ | ENSP00000377771 | ENSP00000379287 | Signal-induced proliferation-associated protein 1; GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression (By similarity). | 14-3-3 protein zeta/delta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). Belongs to the 14-3-3 family. | 0.437 |
SIPA1L1 | LZTS2 | ENSP00000450832 | ENSP00000359240 | Signal-induced proliferation-associated 1-like protein 1; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). | Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. Belongs to the LZTS2 family. | 0.885 |
SIPA1L1 | LZTS3 | ENSP00000450832 | ENSP00000353496 | Signal-induced proliferation-associated 1-like protein 1; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). | Leucine zipper putative tumor suppressor 3; May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses; Belongs to the LZTS3 family. | 0.950 |
SIPA1L1 | SIPA1L2 | ENSP00000450832 | ENSP00000355589 | Signal-induced proliferation-associated 1-like protein 1; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). | Signal-induced proliferation-associated 1-like protein 2; Signal induced proliferation associated 1 like 2. | 0.655 |
SIPA1L1 | SIPA1L3 | ENSP00000450832 | ENSP00000222345 | Signal-induced proliferation-associated 1-like protein 1; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). | Signal-induced proliferation-associated 1-like protein 3; Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens. | 0.648 |
SIPA1L2 | LZTS2 | ENSP00000355589 | ENSP00000359240 | Signal-induced proliferation-associated 1-like protein 2; Signal induced proliferation associated 1 like 2. | Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. Belongs to the LZTS2 family. | 0.634 |
SIPA1L2 | LZTS3 | ENSP00000355589 | ENSP00000353496 | Signal-induced proliferation-associated 1-like protein 2; Signal induced proliferation associated 1 like 2. | Leucine zipper putative tumor suppressor 3; May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses; Belongs to the LZTS3 family. | 0.610 |
SIPA1L2 | SIPA1 | ENSP00000355589 | ENSP00000377771 | Signal-induced proliferation-associated 1-like protein 2; Signal induced proliferation associated 1 like 2. | Signal-induced proliferation-associated protein 1; GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression (By similarity). | 0.659 |
SIPA1L2 | SIPA1L1 | ENSP00000355589 | ENSP00000450832 | Signal-induced proliferation-associated 1-like protein 2; Signal induced proliferation associated 1 like 2. | Signal-induced proliferation-associated 1-like protein 1; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). | 0.655 |
SIPA1L2 | SIPA1L3 | ENSP00000355589 | ENSP00000222345 | Signal-induced proliferation-associated 1-like protein 2; Signal induced proliferation associated 1 like 2. | Signal-induced proliferation-associated 1-like protein 3; Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens. | 0.542 |