node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC107 | LEPROTL1 | ENSP00000414964 | ENSP00000428281 | Coiled-coil domain containing 107. | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Belongs to the OB-RGRP/VPS55 family. | 0.418 |
CCDC107 | TBC1D12 | ENSP00000414964 | ENSP00000225235 | Coiled-coil domain containing 107. | TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth. | 0.513 |
LEPROTL1 | CCDC107 | ENSP00000428281 | ENSP00000414964 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Belongs to the OB-RGRP/VPS55 family. | Coiled-coil domain containing 107. | 0.418 |
LEPROTL1 | PLEKHS1 | ENSP00000428281 | ENSP00000358316 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Belongs to the OB-RGRP/VPS55 family. | Pleckstrin homology domain containing S1. | 0.539 |
LEPROTL1 | TBC1D12 | ENSP00000428281 | ENSP00000225235 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Belongs to the OB-RGRP/VPS55 family. | TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth. | 0.615 |
LEPROTL1 | WDR74 | ENSP00000428281 | ENSP00000432119 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Belongs to the OB-RGRP/VPS55 family. | WD repeat-containing protein 74; Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit. Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL. Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development (By similarity). | 0.504 |
PLCE1 | TBC1D12 | ENSP00000360431 | ENSP00000225235 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T- cell activation. | TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth. | 0.460 |
PLEKHS1 | LEPROTL1 | ENSP00000358316 | ENSP00000428281 | Pleckstrin homology domain containing S1. | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Belongs to the OB-RGRP/VPS55 family. | 0.539 |
PLEKHS1 | TBC1D12 | ENSP00000358316 | ENSP00000225235 | Pleckstrin homology domain containing S1. | TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth. | 0.671 |
PLEKHS1 | WDR74 | ENSP00000358316 | ENSP00000432119 | Pleckstrin homology domain containing S1. | WD repeat-containing protein 74; Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit. Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL. Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development (By similarity). | 0.754 |
SGSM2 | TBC1D12 | ENSP00000268989 | ENSP00000225235 | Small G protein signaling modulator 2; Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation. Belongs to the RUTBC family. | TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth. | 0.519 |
SGSM2 | TBC1D19 | ENSP00000268989 | ENSP00000264866 | Small G protein signaling modulator 2; Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation. Belongs to the RUTBC family. | TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s). | 0.428 |
SGSM2 | TBC1D21 | ENSP00000268989 | ENSP00000300504 | Small G protein signaling modulator 2; Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation. Belongs to the RUTBC family. | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity. | 0.423 |
SGSM2 | TBC1D23 | ENSP00000268989 | ENSP00000377700 | Small G protein signaling modulator 2; Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation. Belongs to the RUTBC family. | TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP- 1. Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly [...] | 0.479 |
TBC1D12 | CCDC107 | ENSP00000225235 | ENSP00000414964 | TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth. | Coiled-coil domain containing 107. | 0.513 |
TBC1D12 | LEPROTL1 | ENSP00000225235 | ENSP00000428281 | TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth. | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Belongs to the OB-RGRP/VPS55 family. | 0.615 |
TBC1D12 | PLCE1 | ENSP00000225235 | ENSP00000360431 | TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T- cell activation. | 0.460 |
TBC1D12 | PLEKHS1 | ENSP00000225235 | ENSP00000358316 | TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth. | Pleckstrin homology domain containing S1. | 0.671 |
TBC1D12 | SGSM2 | ENSP00000225235 | ENSP00000268989 | TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth. | Small G protein signaling modulator 2; Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation. Belongs to the RUTBC family. | 0.519 |
TBC1D12 | TBC1D13 | ENSP00000225235 | ENSP00000361731 | TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth. | TBC1 domain family member 13; Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. | 0.458 |