node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DHDH | G3V4G9_HUMAN | ENSP00000221403 | ENSP00000451792 | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family. | Ig-like domain-containing protein. | 0.411 |
DHDH | GALE | ENSP00000221403 | ENSP00000483375 | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family. | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] | 0.441 |
DHDH | GALK1 | ENSP00000221403 | ENSP00000225614 | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family. | Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily. | 0.830 |
DHDH | GALM | ENSP00000221403 | ENSP00000272252 | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family. | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). | 0.478 |
DHDH | GALT | ENSP00000221403 | ENSP00000368119 | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family. | Galactose-1-phosphate uridylyltransferase; Plays an important role in galactose metabolism. | 0.411 |
DHDH | IL11RA | ENSP00000221403 | ENSP00000450565 | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family. | Interleukin-11 receptor subunit alpha; Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. | 0.411 |
G3V4G9_HUMAN | DHDH | ENSP00000451792 | ENSP00000221403 | Ig-like domain-containing protein. | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family. | 0.411 |
G3V4G9_HUMAN | GALE | ENSP00000451792 | ENSP00000483375 | Ig-like domain-containing protein. | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] | 0.961 |
G3V4G9_HUMAN | GALK1 | ENSP00000451792 | ENSP00000225614 | Ig-like domain-containing protein. | Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily. | 0.922 |
G3V4G9_HUMAN | GALM | ENSP00000451792 | ENSP00000272252 | Ig-like domain-containing protein. | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). | 0.766 |
G3V4G9_HUMAN | UGP2 | ENSP00000451792 | ENSP00000338703 | Ig-like domain-containing protein. | UTP--glucose-1-phosphate uridylyltransferase; Plays a central role as a glucosyl donor in cellular metabolic pathways; Belongs to the UDPGP type 1 family. | 0.743 |
GALE | DHDH | ENSP00000483375 | ENSP00000221403 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family. | 0.441 |
GALE | G3V4G9_HUMAN | ENSP00000483375 | ENSP00000451792 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] | Ig-like domain-containing protein. | 0.961 |
GALE | GALK1 | ENSP00000483375 | ENSP00000225614 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] | Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily. | 0.997 |
GALE | GALM | ENSP00000483375 | ENSP00000272252 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). | 0.988 |
GALE | GALT | ENSP00000483375 | ENSP00000368119 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] | Galactose-1-phosphate uridylyltransferase; Plays an important role in galactose metabolism. | 0.999 |
GALE | IL11RA | ENSP00000483375 | ENSP00000450565 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] | Interleukin-11 receptor subunit alpha; Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. | 0.961 |
GALE | UGP2 | ENSP00000483375 | ENSP00000338703 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] | UTP--glucose-1-phosphate uridylyltransferase; Plays a central role as a glucosyl donor in cellular metabolic pathways; Belongs to the UDPGP type 1 family. | 0.994 |
GALK1 | DHDH | ENSP00000225614 | ENSP00000221403 | Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily. | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family. | 0.830 |
GALK1 | G3V4G9_HUMAN | ENSP00000225614 | ENSP00000451792 | Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily. | Ig-like domain-containing protein. | 0.922 |