STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SYNGR2Synaptogyrin-2; May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane; Belongs to the synaptogyrin family. (275 aa)    
Predicted Functional Partners:
TMC8
Transmembrane channel-like protein 8; Probable ion channel; Belongs to the TMC family.
 
 
  
 0.926
TMC6
Transmembrane channel-like protein 6; Probable ion channel; Belongs to the TMC family.
   
  
 0.907
SYNPR
Synaptoporin; Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity); Belongs to the synaptophysin/synaptobrevin family.
   
 
 0.744
TK1
Thymidine kinase, cytosolic; Thymidine kinase 1; Belongs to the thymidine kinase family.
   
  
 0.743
CANX
Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...]
   
  
 0.642
TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
 
 
    0.521
SCARA3
Scavenger receptor class A member 3; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation.
    
   0.510
ANKFN1
Ankyrin repeat and fibronectin type III domain containing 1.
      
 0.470
TMEM235
Transmembrane protein 235; Belongs to the PMP-22/EMP/MP20 family.
      
 0.446
C17orf67
Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67.
      
 0.435
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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