node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CABS1 | SMR3A | ENSP00000273936 | ENSP00000226460 | Calcium-binding and spermatid-specific protein 1; Calcium binding protein, spermatid associated 1. | Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification. Belongs to the PROL1/PROL3 family. | 0.481 |
CST5 | SMR3A | ENSP00000307132 | ENSP00000226460 | Cystatin-D; Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B. | Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification. Belongs to the PROL1/PROL3 family. | 0.425 |
CST5 | SMR3B | ENSP00000307132 | ENSP00000481313 | Cystatin-D; Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B. | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family. | 0.469 |
FOXO3 | SMR3A | ENSP00000339527 | ENSP00000226460 | Forkhead box protein O3; Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy. Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon [...] | Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification. Belongs to the PROL1/PROL3 family. | 0.410 |
PDPN | SMR3A | ENSP00000294489 | ENSP00000226460 | 29kDa cytosolic podoplanin intracellular domain; Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation. Interaction with CD9, on the contrary, attenuates platelet aggregation induced by PDPN. Through MSN or EZR interaction promotes epithelial- mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and inv [...] | Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification. Belongs to the PROL1/PROL3 family. | 0.410 |
PRB2 | SMR3A | ENSP00000374013 | ENSP00000226460 | Basic salivary proline-rich protein 2; Proline rich protein BstNI subfamily 2. | Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification. Belongs to the PROL1/PROL3 family. | 0.418 |
PRB2 | SMR3B | ENSP00000374013 | ENSP00000481313 | Basic salivary proline-rich protein 2; Proline rich protein BstNI subfamily 2. | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family. | 0.624 |
PTP4A2 | SMR3A | ENSP00000493688 | ENSP00000226460 | Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. | Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification. Belongs to the PROL1/PROL3 family. | 0.541 |
SMR3A | CABS1 | ENSP00000226460 | ENSP00000273936 | Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification. Belongs to the PROL1/PROL3 family. | Calcium-binding and spermatid-specific protein 1; Calcium binding protein, spermatid associated 1. | 0.481 |
SMR3A | CST5 | ENSP00000226460 | ENSP00000307132 | Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification. Belongs to the PROL1/PROL3 family. | Cystatin-D; Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B. | 0.425 |
SMR3A | FOXO3 | ENSP00000226460 | ENSP00000339527 | Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification. Belongs to the PROL1/PROL3 family. | Forkhead box protein O3; Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy. Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon [...] | 0.410 |
SMR3A | PDPN | ENSP00000226460 | ENSP00000294489 | Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification. Belongs to the PROL1/PROL3 family. | 29kDa cytosolic podoplanin intracellular domain; Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation. Interaction with CD9, on the contrary, attenuates platelet aggregation induced by PDPN. Through MSN or EZR interaction promotes epithelial- mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and inv [...] | 0.410 |
SMR3A | PRB2 | ENSP00000226460 | ENSP00000374013 | Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification. Belongs to the PROL1/PROL3 family. | Basic salivary proline-rich protein 2; Proline rich protein BstNI subfamily 2. | 0.418 |
SMR3A | PTP4A2 | ENSP00000226460 | ENSP00000493688 | Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification. Belongs to the PROL1/PROL3 family. | Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. | 0.541 |
SMR3A | SMR3B | ENSP00000226460 | ENSP00000481313 | Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification. Belongs to the PROL1/PROL3 family. | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family. | 0.441 |
SMR3A | VMAC | ENSP00000226460 | ENSP00000343348 | Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification. Belongs to the PROL1/PROL3 family. | Vimentin type intermediate filament associated coiled-coil protein. | 0.618 |
SMR3B | CST5 | ENSP00000481313 | ENSP00000307132 | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family. | Cystatin-D; Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B. | 0.469 |
SMR3B | PRB2 | ENSP00000481313 | ENSP00000374013 | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family. | Basic salivary proline-rich protein 2; Proline rich protein BstNI subfamily 2. | 0.624 |
SMR3B | SMR3A | ENSP00000481313 | ENSP00000226460 | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family. | Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification. Belongs to the PROL1/PROL3 family. | 0.441 |
VMAC | SMR3A | ENSP00000343348 | ENSP00000226460 | Vimentin type intermediate filament associated coiled-coil protein. | Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification. Belongs to the PROL1/PROL3 family. | 0.618 |