STRINGSTRING
RERGL protein (human) - STRING interaction network
"RERGL" - Ras-related and estrogen-regulated growth inhibitor-like protein in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RERGLRas-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family (205 aa)    
Predicted Functional Partners:
C10orf53
Chromosome 10 open reading frame 53 (157 aa)
           
  0.649
PIK3C2G
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity); Belongs to the PI3/PI4-kinase family (1486 aa)
       
 
  0.626
NKIRAS2
NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF- kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity); Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily (191 aa)
           
  0.560
DIRAS1
GTP-binding protein Di-Ras1; Displays low GTPase activity and exists predominantly in the GTP-bound form; RAS type GTPase family (198 aa)
     
   
  0.544
IQSEC3
IQ motif and SEC7 domain-containing protein 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1 (1182 aa)
     
 
  0.526
WSCD2
WSC domain containing 2; Belongs to the WSCD family (565 aa)
     
 
  0.503
ZNF568
Zinc finger protein 568; Has transcriptional repression activity, partially through the recuitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance pr [...] (644 aa)
       
 
  0.465
RASL10A
Ras-like protein family member 10A; Potent inhibitor of cellular proliferation; RAS type GTPase family (203 aa)
           
  0.438
KIAA1467
Protein FAM234B; KIAA1467 (622 aa)
     
   
  0.433
RASEF
Ras and EF-hand domain-containing protein; Binds predominantly GDP, and also GTP; EF-hand domain containing (740 aa)
       
 
  0.430
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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