| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGAP3 | C12orf57 | ENSP00000380413 | ENSP00000229281 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway; Belongs to the centaurin gamma-like family. | Protein C10; In brain, may be required for corpus callosum development. Belongs to the UPF0456 family. | 0.759 |
| AGAP3 | TANC1 | ENSP00000380413 | ENSP00000263635 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway; Belongs to the centaurin gamma-like family. | Protein TANC1; May be a scaffold component in the postsynaptic density. | 0.999 |
| ANKRD50 | C12orf57 | ENSP00000425658 | ENSP00000229281 | Ankyrin repeat domain-containing protein 50; Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. | Protein C10; In brain, may be required for corpus callosum development. Belongs to the UPF0456 family. | 0.999 |
| C12orf57 | AGAP3 | ENSP00000229281 | ENSP00000380413 | Protein C10; In brain, may be required for corpus callosum development. Belongs to the UPF0456 family. | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway; Belongs to the centaurin gamma-like family. | 0.759 |
| C12orf57 | ANKRD50 | ENSP00000229281 | ENSP00000425658 | Protein C10; In brain, may be required for corpus callosum development. Belongs to the UPF0456 family. | Ankyrin repeat domain-containing protein 50; Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. | 0.999 |
| C12orf57 | HLA-B | ENSP00000229281 | ENSP00000399168 | Protein C10; In brain, may be required for corpus callosum development. Belongs to the UPF0456 family. | HLA class I histocompatibility antigen, B alpha chain; Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells. May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usuall [...] | 0.663 |
| C12orf57 | PLAC8 | ENSP00000229281 | ENSP00000399700 | Protein C10; In brain, may be required for corpus callosum development. Belongs to the UPF0456 family. | Placenta-specific gene 8 protein; Placenta associated 8. | 0.772 |
| C12orf57 | PLXNB2 | ENSP00000229281 | ENSP00000352288 | Protein C10; In brain, may be required for corpus callosum development. Belongs to the UPF0456 family. | Plexin-B2; Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is required for SEMA4A- mediated excitatory synapse development (By similarity). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity). Regulates the migration of cerebellar g [...] | 0.881 |
| C12orf57 | POLR3H | ENSP00000229281 | ENSP00000347345 | Protein C10; In brain, may be required for corpus callosum development. Belongs to the UPF0456 family. | DNA-directed RNA polymerase III subunit RPC8; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Ep [...] | 0.656 |
| C12orf57 | PPP1CA | ENSP00000229281 | ENSP00000326031 | Protein C10; In brain, may be required for corpus callosum development. Belongs to the UPF0456 family. | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] | 0.622 |
| C12orf57 | TACC1 | ENSP00000229281 | ENSP00000321703 | Protein C10; In brain, may be required for corpus callosum development. Belongs to the UPF0456 family. | Transforming acidic coiled-coil-containing protein 1; Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways. Might promote the nuclear localization of the receptors. Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. Belongs to the TACC family. | 0.840 |
| C12orf57 | TANC1 | ENSP00000229281 | ENSP00000263635 | Protein C10; In brain, may be required for corpus callosum development. Belongs to the UPF0456 family. | Protein TANC1; May be a scaffold component in the postsynaptic density. | 0.906 |
| C12orf57 | TANC2 | ENSP00000229281 | ENSP00000387593 | Protein C10; In brain, may be required for corpus callosum development. Belongs to the UPF0456 family. | Protein TANC2; Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. | 0.629 |
| HLA-B | C12orf57 | ENSP00000399168 | ENSP00000229281 | HLA class I histocompatibility antigen, B alpha chain; Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells. May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usuall [...] | Protein C10; In brain, may be required for corpus callosum development. Belongs to the UPF0456 family. | 0.663 |
| PLAC8 | C12orf57 | ENSP00000399700 | ENSP00000229281 | Placenta-specific gene 8 protein; Placenta associated 8. | Protein C10; In brain, may be required for corpus callosum development. Belongs to the UPF0456 family. | 0.772 |
| PLAC8 | POLR3H | ENSP00000399700 | ENSP00000347345 | Placenta-specific gene 8 protein; Placenta associated 8. | DNA-directed RNA polymerase III subunit RPC8; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Ep [...] | 0.716 |
| PLXNB2 | C12orf57 | ENSP00000352288 | ENSP00000229281 | Plexin-B2; Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is required for SEMA4A- mediated excitatory synapse development (By similarity). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity). Regulates the migration of cerebellar g [...] | Protein C10; In brain, may be required for corpus callosum development. Belongs to the UPF0456 family. | 0.881 |
| PLXNB2 | TACC1 | ENSP00000352288 | ENSP00000321703 | Plexin-B2; Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is required for SEMA4A- mediated excitatory synapse development (By similarity). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity). Regulates the migration of cerebellar g [...] | Transforming acidic coiled-coil-containing protein 1; Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways. Might promote the nuclear localization of the receptors. Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. Belongs to the TACC family. | 0.938 |
| POLR3H | C12orf57 | ENSP00000347345 | ENSP00000229281 | DNA-directed RNA polymerase III subunit RPC8; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Ep [...] | Protein C10; In brain, may be required for corpus callosum development. Belongs to the UPF0456 family. | 0.656 |
| POLR3H | PLAC8 | ENSP00000347345 | ENSP00000399700 | DNA-directed RNA polymerase III subunit RPC8; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Ep [...] | Placenta-specific gene 8 protein; Placenta associated 8. | 0.716 |
