Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AIPL1 | C8orf37 | ENSP00000370521 | ENSP00000286688 | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization; FKBP prolyl isomerases | Protein C8orf37; Chromosome 8 open reading frame 37; Bardet-Biedl syndrome associated | 0.451 |
| AIPL1 | CRB1 | ENSP00000370521 | ENSP00000356370 | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization; FKBP prolyl isomerases | Protein crumbs homolog 1; Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion; Belongs to the Crumbs protein family | 0.847 |
| AIPL1 | GUCY2D | ENSP00000370521 | ENSP00000254854 | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization; FKBP prolyl isomerases | Retinal guanylyl cyclase 1; Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction; Guanylate cyclase receptors | 0.874 |
| AIPL1 | LCA5 | ENSP00000370521 | ENSP00000376686 | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization; FKBP prolyl isomerases | LCA5, lebercilin; Lebercilin; Might be involved in minus end-directed microtubule transport | 0.783 |
| AIPL1 | LRAT | ENSP00000370521 | ENSP00000337224 | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization; FKBP prolyl isomerases | Phosphatidylcholine-retinol o-acyltransferase; Lecithin retinol acyltransferase; Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromop [...] | 0.710 |
| AIPL1 | MERTK | ENSP00000370521 | ENSP00000295408 | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization; FKBP prolyl isomerases | Tyrosine-protein kinase Mer; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation [...] | 0.565 |
| AIPL1 | RDH12 | ENSP00000370521 | ENSP00000449079 | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization; FKBP prolyl isomerases | Retinol dehydrogenase 12; Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments | 0.815 |
| AIPL1 | RPE65 | ENSP00000370521 | ENSP00000262340 | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization; FKBP prolyl isomerases | Retinoid isomerohydrolase / lutein isomerase; Retinoid isomerohydrolase; Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans- retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carote [...] | 0.808 |
| AIPL1 | SPATA7 | ENSP00000370521 | ENSP00000377176 | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization; FKBP prolyl isomerases | Spermatogenesis-associated protein 7; Involved in photoreceptor cells maintenance (By similarity). It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as protein trafficking across the CC to the outer segments (By similarity) | 0.756 |
| AIPL1 | TULP1 | ENSP00000370521 | ENSP00000229771 | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization; FKBP prolyl isomerases | Tubby-related protein 1; Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long- term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4- phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vit [...] | 0.825 |
| C8orf37 | AIPL1 | ENSP00000286688 | ENSP00000370521 | Protein C8orf37; Chromosome 8 open reading frame 37; Bardet-Biedl syndrome associated | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization; FKBP prolyl isomerases | 0.451 |
| C8orf37 | CRB1 | ENSP00000286688 | ENSP00000356370 | Protein C8orf37; Chromosome 8 open reading frame 37; Bardet-Biedl syndrome associated | Protein crumbs homolog 1; Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion; Belongs to the Crumbs protein family | 0.544 |
| C8orf37 | GUCY2D | ENSP00000286688 | ENSP00000254854 | Protein C8orf37; Chromosome 8 open reading frame 37; Bardet-Biedl syndrome associated | Retinal guanylyl cyclase 1; Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction; Guanylate cyclase receptors | 0.529 |
| C8orf37 | LRAT | ENSP00000286688 | ENSP00000337224 | Protein C8orf37; Chromosome 8 open reading frame 37; Bardet-Biedl syndrome associated | Phosphatidylcholine-retinol o-acyltransferase; Lecithin retinol acyltransferase; Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromop [...] | 0.481 |
| C8orf37 | RDH12 | ENSP00000286688 | ENSP00000449079 | Protein C8orf37; Chromosome 8 open reading frame 37; Bardet-Biedl syndrome associated | Retinol dehydrogenase 12; Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments | 0.586 |
| C8orf37 | RPE65 | ENSP00000286688 | ENSP00000262340 | Protein C8orf37; Chromosome 8 open reading frame 37; Bardet-Biedl syndrome associated | Retinoid isomerohydrolase / lutein isomerase; Retinoid isomerohydrolase; Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans- retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carote [...] | 0.469 |
| C8orf37 | SPATA7 | ENSP00000286688 | ENSP00000377176 | Protein C8orf37; Chromosome 8 open reading frame 37; Bardet-Biedl syndrome associated | Spermatogenesis-associated protein 7; Involved in photoreceptor cells maintenance (By similarity). It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as protein trafficking across the CC to the outer segments (By similarity) | 0.587 |
| C8orf37 | TULP1 | ENSP00000286688 | ENSP00000229771 | Protein C8orf37; Chromosome 8 open reading frame 37; Bardet-Biedl syndrome associated | Tubby-related protein 1; Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long- term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4- phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vit [...] | 0.765 |
| CRB1 | AIPL1 | ENSP00000356370 | ENSP00000370521 | Protein crumbs homolog 1; Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion; Belongs to the Crumbs protein family | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization; FKBP prolyl isomerases | 0.847 |
| CRB1 | C8orf37 | ENSP00000356370 | ENSP00000286688 | Protein crumbs homolog 1; Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion; Belongs to the Crumbs protein family | Protein C8orf37; Chromosome 8 open reading frame 37; Bardet-Biedl syndrome associated | 0.544 |
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