GPR63 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD61	FAM110D	ENSP00000386502	ENSP00000363386	Ankyrin repeat domain 61.	Protein FAM110D; Family with sequence similarity 110 member D; Belongs to the FAM110 family.	0.665
ANKRD61	GPR63	ENSP00000386502	ENSP00000229955	Ankyrin repeat domain 61.	Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.	0.465
FAM110D	ANKRD61	ENSP00000363386	ENSP00000386502	Protein FAM110D; Family with sequence similarity 110 member D; Belongs to the FAM110 family.	Ankyrin repeat domain 61.	0.665
FAM110D	GPR63	ENSP00000363386	ENSP00000229955	Protein FAM110D; Family with sequence similarity 110 member D; Belongs to the FAM110 family.	Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.	0.470
GPR150	GPR27	ENSP00000369344	ENSP00000303149	Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.	Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.	0.608
GPR150	GPR61	ENSP00000369344	ENSP00000432456	Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.	G-protein coupled receptor 61; Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway. Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization. May be involved in the regulation of food intake and body weight (By similarity).	0.447
GPR150	GPR63	ENSP00000369344	ENSP00000229955	Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.	Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.	0.466
GPR150	GPR88	ENSP00000369344	ENSP00000314223	Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.	Probable G-protein coupled receptor 88; Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function.	0.486
GPR22	GPR63	ENSP00000302676	ENSP00000229955	G-protein coupled receptor 22; Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway. May be involved in ciliogenesis (By similarity).	Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.	0.554
GPR22	KLHL32	ENSP00000302676	ENSP00000358265	G-protein coupled receptor 22; Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway. May be involved in ciliogenesis (By similarity).	Kelch-like protein 32; Kelch like family member 32.	0.482
GPR27	GPR150	ENSP00000303149	ENSP00000369344	Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.	Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.	0.608
GPR27	GPR63	ENSP00000303149	ENSP00000229955	Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.	Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.	0.524
GPR61	GPR150	ENSP00000432456	ENSP00000369344	G-protein coupled receptor 61; Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway. Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization. May be involved in the regulation of food intake and body weight (By similarity).	Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.	0.447
GPR61	GPR63	ENSP00000432456	ENSP00000229955	G-protein coupled receptor 61; Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway. Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization. May be involved in the regulation of food intake and body weight (By similarity).	Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.	0.465
GPR63	ANKRD61	ENSP00000229955	ENSP00000386502	Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.	Ankyrin repeat domain 61.	0.465
GPR63	FAM110D	ENSP00000229955	ENSP00000363386	Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.	Protein FAM110D; Family with sequence similarity 110 member D; Belongs to the FAM110 family.	0.470
GPR63	GPR150	ENSP00000229955	ENSP00000369344	Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.	Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.	0.466
GPR63	GPR22	ENSP00000229955	ENSP00000302676	Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.	G-protein coupled receptor 22; Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway. May be involved in ciliogenesis (By similarity).	0.554
GPR63	GPR27	ENSP00000229955	ENSP00000303149	Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.	Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.	0.524
GPR63	GPR61	ENSP00000229955	ENSP00000432456	Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.	G-protein coupled receptor 61; Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway. Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization. May be involved in the regulation of food intake and body weight (By similarity).	0.465