C1orf21 protein (human) - STRING interaction network

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C1orf21

Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21. (121 aa)

Predicted Functional Partners:

PPP2R5A

0.622

TMEM131L

0.477

TMEM185A

0.456

PPP2R5B

0.453

SPPL2C

0.434

PPP2R5E

0.425

NKAPD1

0.412

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf21	NKAPD1	ENSP00000235307	ENSP00000376767	Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21.	Uncharacterized protein NKAPD1; NKAP domain containing 1.	0.412
C1orf21	PPP2R5A	ENSP00000235307	ENSP00000261461	Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.622
C1orf21	PPP2R5B	ENSP00000235307	ENSP00000164133	Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.	0.453
C1orf21	PPP2R5E	ENSP00000235307	ENSP00000337641	Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment; Belongs to the phosphatase 2A regulatory subunit B56 family.	0.425
C1orf21	SPPL2C	ENSP00000235307	ENSP00000332488	Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21.	Signal peptide peptidase-like 2C; Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane.	0.434
C1orf21	TMEM131L	ENSP00000235307	ENSP00000386787	Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21.	Transmembrane protein 131-like; [Isoform 1]: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.	0.477
C1orf21	TMEM185A	ENSP00000235307	ENSP00000471932	Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21.	Transmembrane protein 185A; Belongs to the TMEM185 family.	0.456
NKAPD1	C1orf21	ENSP00000376767	ENSP00000235307	Uncharacterized protein NKAPD1; NKAP domain containing 1.	Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21.	0.412
PPP2R5A	C1orf21	ENSP00000261461	ENSP00000235307	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21.	0.622
PPP2R5A	PPP2R5B	ENSP00000261461	ENSP00000164133	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.	0.848
PPP2R5A	PPP2R5E	ENSP00000261461	ENSP00000337641	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment; Belongs to the phosphatase 2A regulatory subunit B56 family.	0.915
PPP2R5B	C1orf21	ENSP00000164133	ENSP00000235307	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.	Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21.	0.453
PPP2R5B	PPP2R5A	ENSP00000164133	ENSP00000261461	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.848
PPP2R5B	PPP2R5E	ENSP00000164133	ENSP00000337641	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment; Belongs to the phosphatase 2A regulatory subunit B56 family.	0.725
PPP2R5E	C1orf21	ENSP00000337641	ENSP00000235307	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment; Belongs to the phosphatase 2A regulatory subunit B56 family.	Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21.	0.425
PPP2R5E	PPP2R5A	ENSP00000337641	ENSP00000261461	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment; Belongs to the phosphatase 2A regulatory subunit B56 family.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.915
PPP2R5E	PPP2R5B	ENSP00000337641	ENSP00000164133	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment; Belongs to the phosphatase 2A regulatory subunit B56 family.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.	0.725
SPPL2C	C1orf21	ENSP00000332488	ENSP00000235307	Signal peptide peptidase-like 2C; Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane.	Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21.	0.434
TMEM131L	C1orf21	ENSP00000386787	ENSP00000235307	Transmembrane protein 131-like; [Isoform 1]: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.	Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21.	0.477
TMEM185A	C1orf21	ENSP00000471932	ENSP00000235307	Transmembrane protein 185A; Belongs to the TMEM185 family.	Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21.	0.456