node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP5PB | SLC19A2 | ENSP00000358737 | ENSP00000236137 | ATP synthase F(0) complex subunit B1, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechani [...] | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | 0.601 |
BTD | SLC19A2 | ENSP00000500193 | ENSP00000236137 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | 0.619 |
BTD | SLC19A3 | ENSP00000500193 | ENSP00000495385 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | Thiamine transporter 2; Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity. Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. | 0.732 |
IER3IP1 | RFX6 | ENSP00000256433 | ENSP00000332208 | Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity); Belongs to the YOS1 family. | DNA-binding protein RFX6; Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by [...] | 0.659 |
IER3IP1 | SLC19A2 | ENSP00000256433 | ENSP00000236137 | Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity); Belongs to the YOS1 family. | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | 0.664 |
IER3IP1 | WFS1 | ENSP00000256433 | ENSP00000226760 | Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity); Belongs to the YOS1 family. | Wolframin; Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. | 0.593 |
RFX6 | IER3IP1 | ENSP00000332208 | ENSP00000256433 | DNA-binding protein RFX6; Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by [...] | Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity); Belongs to the YOS1 family. | 0.659 |
RFX6 | SLC19A2 | ENSP00000332208 | ENSP00000236137 | DNA-binding protein RFX6; Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by [...] | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | 0.605 |
RFX6 | WFS1 | ENSP00000332208 | ENSP00000226760 | DNA-binding protein RFX6; Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by [...] | Wolframin; Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. | 0.571 |
SLC19A2 | ATP5PB | ENSP00000236137 | ENSP00000358737 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | ATP synthase F(0) complex subunit B1, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechani [...] | 0.601 |
SLC19A2 | BTD | ENSP00000236137 | ENSP00000500193 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | 0.619 |
SLC19A2 | IER3IP1 | ENSP00000236137 | ENSP00000256433 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity); Belongs to the YOS1 family. | 0.664 |
SLC19A2 | RFX6 | ENSP00000236137 | ENSP00000332208 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | DNA-binding protein RFX6; Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by [...] | 0.605 |
SLC19A2 | SLC19A3 | ENSP00000236137 | ENSP00000495385 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | Thiamine transporter 2; Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity. Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. | 0.909 |
SLC19A2 | SLC25A19 | ENSP00000236137 | ENSP00000385312 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | Mitochondrial thiamine pyrophosphate carrier; Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria. | 0.653 |
SLC19A2 | SLC25A38 | ENSP00000236137 | ENSP00000497532 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. | 0.578 |
SLC19A2 | TPK1 | ENSP00000236137 | ENSP00000353165 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | Thiamin pyrophosphokinase 1; Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate. | 0.755 |
SLC19A2 | TSPAN1 | ENSP00000236137 | ENSP00000361072 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | Tetraspanin-1; Tetraspanin 1. | 0.749 |
SLC19A2 | WFS1 | ENSP00000236137 | ENSP00000226760 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | Wolframin; Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. | 0.580 |
SLC19A3 | BTD | ENSP00000495385 | ENSP00000500193 | Thiamine transporter 2; Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity. Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | 0.732 |