MSANTD2 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	MSANTD2	ENSP00000220592	ENSP00000364118	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Myb/SANT-like DNA-binding domain-containing protein 2; Myb/SANT DNA binding domain containing 2.	0.470
AGO2	SHCBP1	ENSP00000220592	ENSP00000306473	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	SHC SH2 domain-binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.	0.511
AGO2	TLK2	ENSP00000220592	ENSP00000316512	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Serine/threonine-protein kinase tousled-like 2; Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.	0.504
DSTYK	MSANTD2	ENSP00000356130	ENSP00000364118	Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.	Myb/SANT-like DNA-binding domain-containing protein 2; Myb/SANT DNA binding domain containing 2.	0.439
LUC7L3	MSANTD2	ENSP00000376919	ENSP00000364118	Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing.	Myb/SANT-like DNA-binding domain-containing protein 2; Myb/SANT DNA binding domain containing 2.	0.481
MSANTD1	MSANTD2	ENSP00000411584	ENSP00000364118	Myb/SANT-like DNA-binding domain-containing protein 1; Myb/SANT DNA binding domain containing 1.	Myb/SANT-like DNA-binding domain-containing protein 2; Myb/SANT DNA binding domain containing 2.	0.401
MSANTD2	AGO2	ENSP00000364118	ENSP00000220592	Myb/SANT-like DNA-binding domain-containing protein 2; Myb/SANT DNA binding domain containing 2.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.470
MSANTD2	DSTYK	ENSP00000364118	ENSP00000356130	Myb/SANT-like DNA-binding domain-containing protein 2; Myb/SANT DNA binding domain containing 2.	Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.	0.439
MSANTD2	LUC7L3	ENSP00000364118	ENSP00000376919	Myb/SANT-like DNA-binding domain-containing protein 2; Myb/SANT DNA binding domain containing 2.	Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing.	0.481
MSANTD2	MSANTD1	ENSP00000364118	ENSP00000411584	Myb/SANT-like DNA-binding domain-containing protein 2; Myb/SANT DNA binding domain containing 2.	Myb/SANT-like DNA-binding domain-containing protein 1; Myb/SANT DNA binding domain containing 1.	0.401
MSANTD2	MSANTD3	ENSP00000364118	ENSP00000480445	Myb/SANT-like DNA-binding domain-containing protein 2; Myb/SANT DNA binding domain containing 2.	Myb/SANT-like DNA-binding domain-containing protein 3; Myb/SANT DNA binding domain containing 3; Belongs to the MSANTD3 family.	0.456
MSANTD2	RAB30	ENSP00000364118	ENSP00000435189	Myb/SANT-like DNA-binding domain-containing protein 2; Myb/SANT DNA binding domain containing 2.	Ras-related protein Rab-30; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins.	0.473
MSANTD2	SHCBP1	ENSP00000364118	ENSP00000306473	Myb/SANT-like DNA-binding domain-containing protein 2; Myb/SANT DNA binding domain containing 2.	SHC SH2 domain-binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.	0.457
MSANTD2	TLK2	ENSP00000364118	ENSP00000316512	Myb/SANT-like DNA-binding domain-containing protein 2; Myb/SANT DNA binding domain containing 2.	Serine/threonine-protein kinase tousled-like 2; Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.	0.471
MSANTD3	MSANTD2	ENSP00000480445	ENSP00000364118	Myb/SANT-like DNA-binding domain-containing protein 3; Myb/SANT DNA binding domain containing 3; Belongs to the MSANTD3 family.	Myb/SANT-like DNA-binding domain-containing protein 2; Myb/SANT DNA binding domain containing 2.	0.456
RAB30	MSANTD2	ENSP00000435189	ENSP00000364118	Ras-related protein Rab-30; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins.	Myb/SANT-like DNA-binding domain-containing protein 2; Myb/SANT DNA binding domain containing 2.	0.473
SHCBP1	AGO2	ENSP00000306473	ENSP00000220592	SHC SH2 domain-binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.511
SHCBP1	MSANTD2	ENSP00000306473	ENSP00000364118	SHC SH2 domain-binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.	Myb/SANT-like DNA-binding domain-containing protein 2; Myb/SANT DNA binding domain containing 2.	0.457
TLK2	AGO2	ENSP00000316512	ENSP00000220592	Serine/threonine-protein kinase tousled-like 2; Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.504
TLK2	MSANTD2	ENSP00000316512	ENSP00000364118	Serine/threonine-protein kinase tousled-like 2; Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.	Myb/SANT-like DNA-binding domain-containing protein 2; Myb/SANT DNA binding domain containing 2.	0.471