node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PEX10 | PEX12 | ENSP00000288774 | ENSP00000482609 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | 0.999 |
PEX10 | PEX13 | ENSP00000288774 | ENSP00000295030 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins. | 0.998 |
PEX10 | PEX14 | ENSP00000288774 | ENSP00000349016 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisomal membrane protein PEX14; Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin. | 0.985 |
PEX10 | PEX16 | ENSP00000288774 | ENSP00000241041 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisomal membrane protein PEX16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3. Belongs to the peroxin-16 family. | 0.962 |
PEX10 | PEX19 | ENSP00000288774 | ENSP00000357051 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. | 0.994 |
PEX10 | PEX2 | ENSP00000288774 | ENSP00000349543 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family. | 0.999 |
PEX10 | PEX26 | ENSP00000288774 | ENSP00000331106 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisome assembly protein 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence. | 0.970 |
PEX10 | PEX3 | ENSP00000288774 | ENSP00000356563 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes; Belongs to the peroxin-3 family. | 0.964 |
PEX10 | PEX5 | ENSP00000288774 | ENSP00000391601 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | 0.995 |
PEX10 | PEX6 | ENSP00000288774 | ENSP00000303511 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. | 0.989 |
PEX12 | PEX10 | ENSP00000482609 | ENSP00000288774 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | 0.999 |
PEX12 | PEX13 | ENSP00000482609 | ENSP00000295030 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins. | 0.999 |
PEX12 | PEX14 | ENSP00000482609 | ENSP00000349016 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisomal membrane protein PEX14; Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin. | 0.996 |
PEX12 | PEX16 | ENSP00000482609 | ENSP00000241041 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisomal membrane protein PEX16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3. Belongs to the peroxin-16 family. | 0.980 |
PEX12 | PEX19 | ENSP00000482609 | ENSP00000357051 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. | 0.995 |
PEX12 | PEX2 | ENSP00000482609 | ENSP00000349543 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family. | 0.999 |
PEX12 | PEX26 | ENSP00000482609 | ENSP00000331106 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisome assembly protein 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence. | 0.963 |
PEX12 | PEX3 | ENSP00000482609 | ENSP00000356563 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes; Belongs to the peroxin-3 family. | 0.992 |
PEX12 | PEX5 | ENSP00000482609 | ENSP00000391601 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | 0.998 |
PEX12 | PEX6 | ENSP00000482609 | ENSP00000303511 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. | 0.988 |