node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C21orf62 | FAM149B1 | ENSP00000418653 | ENSP00000242505 | Uncharacterized protein C21orf62; Chromosome 21 open reading frame 62. | Protein FAM149B1; Family with sequence similarity 149 member B1. | 0.470 |
CFAP20 | FAM149B1 | ENSP00000262498 | ENSP00000242505 | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation. | Protein FAM149B1; Family with sequence similarity 149 member B1. | 0.826 |
CFAP20 | TBC1D32 | ENSP00000262498 | ENSP00000381270 | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation. | Protein broad-minded; Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling (By similarity). | 0.883 |
DNAJB4 | DNAJC9 | ENSP00000359799 | ENSP00000362041 | DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | DnaJ homolog subfamily C member 9; May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8. | 0.621 |
DNAJB4 | FAM149B1 | ENSP00000359799 | ENSP00000242505 | DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | Protein FAM149B1; Family with sequence similarity 149 member B1. | 0.555 |
DNAJC9 | DNAJB4 | ENSP00000362041 | ENSP00000359799 | DnaJ homolog subfamily C member 9; May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8. | DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | 0.621 |
DNAJC9 | FAM149B1 | ENSP00000362041 | ENSP00000242505 | DnaJ homolog subfamily C member 9; May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8. | Protein FAM149B1; Family with sequence similarity 149 member B1. | 0.967 |
ENOX2 | FAM149B1 | ENSP00000337146 | ENSP00000242505 | Protein disulfide-thiol oxidoreductase; May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. | Protein FAM149B1; Family with sequence similarity 149 member B1. | 0.471 |
FAM149B1 | C21orf62 | ENSP00000242505 | ENSP00000418653 | Protein FAM149B1; Family with sequence similarity 149 member B1. | Uncharacterized protein C21orf62; Chromosome 21 open reading frame 62. | 0.470 |
FAM149B1 | CFAP20 | ENSP00000242505 | ENSP00000262498 | Protein FAM149B1; Family with sequence similarity 149 member B1. | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation. | 0.826 |
FAM149B1 | DNAJB4 | ENSP00000242505 | ENSP00000359799 | Protein FAM149B1; Family with sequence similarity 149 member B1. | DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | 0.555 |
FAM149B1 | DNAJC9 | ENSP00000242505 | ENSP00000362041 | Protein FAM149B1; Family with sequence similarity 149 member B1. | DnaJ homolog subfamily C member 9; May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8. | 0.967 |
FAM149B1 | ENOX2 | ENSP00000242505 | ENSP00000337146 | Protein FAM149B1; Family with sequence similarity 149 member B1. | Protein disulfide-thiol oxidoreductase; May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. | 0.471 |
FAM149B1 | HAL | ENSP00000242505 | ENSP00000261208 | Protein FAM149B1; Family with sequence similarity 149 member B1. | Histidine ammonia-lyase. | 0.541 |
FAM149B1 | LRRC69 | ENSP00000242505 | ENSP00000343221 | Protein FAM149B1; Family with sequence similarity 149 member B1. | Leucine-rich repeat-containing protein 69; Leucine rich repeat containing 69. | 0.479 |
FAM149B1 | NEU1 | ENSP00000242505 | ENSP00000364782 | Protein FAM149B1; Family with sequence similarity 149 member B1. | Sialidase-1; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. | 0.451 |
FAM149B1 | TBC1D32 | ENSP00000242505 | ENSP00000381270 | Protein FAM149B1; Family with sequence similarity 149 member B1. | Protein broad-minded; Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling (By similarity). | 0.886 |
FAM149B1 | TMEM260 | ENSP00000242505 | ENSP00000261556 | Protein FAM149B1; Family with sequence similarity 149 member B1. | Transmembrane protein 260; Belongs to the TMEM260 family. | 0.465 |
HAL | FAM149B1 | ENSP00000261208 | ENSP00000242505 | Histidine ammonia-lyase. | Protein FAM149B1; Family with sequence similarity 149 member B1. | 0.541 |
LRRC69 | FAM149B1 | ENSP00000343221 | ENSP00000242505 | Leucine-rich repeat-containing protein 69; Leucine rich repeat containing 69. | Protein FAM149B1; Family with sequence similarity 149 member B1. | 0.479 |