node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTA1 | MYH1 | ENSP00000355645 | ENSP00000226207 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Myosin-1; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.892 |
ACTA1 | MYH13 | ENSP00000355645 | ENSP00000404570 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Myosin-13; Fast twitching myosin mediating the high-velocity and low- tension contractions of specific striated muscles. | 0.593 |
ACTA1 | MYH2 | ENSP00000355645 | ENSP00000380367 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). | 0.946 |
ACTA1 | MYH6 | ENSP00000355645 | ENSP00000386041 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Myosin-6; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.747 |
ACTA1 | MYH7 | ENSP00000355645 | ENSP00000347507 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. | 0.945 |
ACTA1 | MYH8 | ENSP00000355645 | ENSP00000384330 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Myosin-8; Muscle contraction. | 0.665 |
ACTA1 | MYL1 | ENSP00000355645 | ENSP00000307280 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.964 |
ACTA1 | MYL2 | ENSP00000355645 | ENSP00000228841 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | 0.926 |
ACTA1 | MYL3 | ENSP00000355645 | ENSP00000499406 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | 0.663 |
ACTA1 | MYLPF | ENSP00000355645 | ENSP00000325239 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Myosin light chain, phosphorylatable, fast skeletal muscle. | 0.915 |
MYH1 | ACTA1 | ENSP00000226207 | ENSP00000355645 | Myosin-1; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | 0.892 |
MYH1 | MYH13 | ENSP00000226207 | ENSP00000404570 | Myosin-1; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Myosin-13; Fast twitching myosin mediating the high-velocity and low- tension contractions of specific striated muscles. | 0.943 |
MYH1 | MYH2 | ENSP00000226207 | ENSP00000380367 | Myosin-1; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). | 0.990 |
MYH1 | MYH6 | ENSP00000226207 | ENSP00000386041 | Myosin-1; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Myosin-6; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.915 |
MYH1 | MYH7 | ENSP00000226207 | ENSP00000347507 | Myosin-1; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. | 0.962 |
MYH1 | MYH8 | ENSP00000226207 | ENSP00000384330 | Myosin-1; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Myosin-8; Muscle contraction. | 0.942 |
MYH1 | MYL1 | ENSP00000226207 | ENSP00000307280 | Myosin-1; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.989 |
MYH1 | MYL2 | ENSP00000226207 | ENSP00000228841 | Myosin-1; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | 0.945 |
MYH1 | MYL3 | ENSP00000226207 | ENSP00000499406 | Myosin-1; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | 0.921 |
MYH1 | MYLPF | ENSP00000226207 | ENSP00000325239 | Myosin-1; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Myosin light chain, phosphorylatable, fast skeletal muscle. | 0.974 |