STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ARMC7Armadillo repeat containing 7. (198 aa)    
Predicted Functional Partners:
RBM48
RNA binding motif protein 48; Belongs to the RBM48 family.
  
 
 
 0.996
SCNM1
Sodium channel modifier 1; Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.
   
 
 0.949
PPIL2
RING-type E3 ubiquitin-protein ligase PPIL2; Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'- linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl- prolyl cis-trans isomerase activity. Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
   
 
 0.943
CRIPT
Cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses.
    
 
 0.942
GPKOW
G-patch domain and KOW motifs-containing protein; RNA-binding protein involved in pre-mRNA splicing.
   
   0.936
BUD13
BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome.
   
   0.929
DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; Required for pre-mRNA splicing as component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction.
   
   0.925
RNF113A
E3 ubiquitin-protein ligase RNF113A; Required for pre-mRNA splicing as component of the spliceosome. E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling.
   
   0.924
SF3B4
Splicing factor 3B subunit 4; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare clas [...]
   
   0.923
SRRM2
Serine/arginine repetitive matrix protein 2; Required for pre-mRNA splicing as component of the spliceosome. Belongs to the CWC21 family.
   
 
 0.923
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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