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UROD protein (human) - STRING interaction network
"UROD" - Uroporphyrinogen decarboxylase in Homo sapiens
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
URODUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (367 aa)    
Predicted Functional Partners:
CPOX
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (454 aa)
   
 
  0.998
UROS
Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (265 aa)
   
 
  0.994
PPOX
Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX (477 aa)
   
 
  0.993
HMBS
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps; Belongs to the HMBS family (361 aa)
 
  0.993
ALAD
Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen; Belongs to the ALAD family (330 aa)
 
 
  0.961
FECH
Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX; Belongs to the ferrochelatase family (429 aa)
 
   
  0.947
FAM84B
Protein FAM84B; Family with sequence similarity 84 member B; Belongs to the FAM84 family (310 aa)
       
      0.766
ALAS2
5-aminolevulinate synthase, erythroid-specific, mitochondrial; 5’-aminolevulinate synthase 2 (587 aa)
   
   
  0.760
TPI1
Triosephosphate isomerase 1; Belongs to the triosephosphate isomerase family (286 aa)
   
   
  0.750
ALAS1
5-aminolevulinate synthase, nonspecific, mitochondrial; 5’-aminolevulinate synthase 1; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family (640 aa)
   
   
  0.746
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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