PDCD2L protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

PDCD2L

Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase. (358 aa)

Predicted Functional Partners:

PRMT3

0.998

RPS2

0.897

NAP1L5

0.890

ITGB1BP2

0.854

ATG2B

0.801

SLX4IP

0.756

H7C0V5_HUMAN

0.715

ZNF277

0.608

BYSL

0.606

SNX27

0.583

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG2B	PDCD2L	ENSP00000353010	ENSP00000246535	Autophagy-related protein 2 homolog B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion; Belongs to the ATG2 family.	Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.	0.801
BYSL	PDCD2L	ENSP00000230340	ENSP00000246535	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin- dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family.	Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.	0.606
BYSL	RPS2	ENSP00000230340	ENSP00000341885	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin- dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family.	Ribosomal protein S2.	0.997
H7C0V5_HUMAN	PDCD2L	ENSP00000432016	ENSP00000246535	ANKHD1-EIF4EBP3 readthrough.	Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.	0.715
ITGB1BP2	PDCD2L	ENSP00000362935	ENSP00000246535	Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells.	Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.	0.854
NAP1L5	PDCD2L	ENSP00000320488	ENSP00000246535	Nucleosome assembly protein 1 like 5.	Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.	0.890
NAP1L5	RPS2	ENSP00000320488	ENSP00000341885	Nucleosome assembly protein 1 like 5.	Ribosomal protein S2.	0.544
PDCD2L	ATG2B	ENSP00000246535	ENSP00000353010	Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.	Autophagy-related protein 2 homolog B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion; Belongs to the ATG2 family.	0.801
PDCD2L	BYSL	ENSP00000246535	ENSP00000230340	Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin- dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family.	0.606
PDCD2L	H7C0V5_HUMAN	ENSP00000246535	ENSP00000432016	Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.	ANKHD1-EIF4EBP3 readthrough.	0.715
PDCD2L	ITGB1BP2	ENSP00000246535	ENSP00000362935	Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.	Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells.	0.854
PDCD2L	NAP1L5	ENSP00000246535	ENSP00000320488	Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.	Nucleosome assembly protein 1 like 5.	0.890
PDCD2L	PRMT3	ENSP00000246535	ENSP00000331879	Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.	Protein arginine N-methyltransferase 3; Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.	0.998
PDCD2L	RPS2	ENSP00000246535	ENSP00000341885	Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.	Ribosomal protein S2.	0.897
PDCD2L	SLX4IP	ENSP00000246535	ENSP00000335557	Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.	SLX4 interacting protein.	0.756
PDCD2L	SNX27	ENSP00000246535	ENSP00000400333	Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.	Sorting nexin-27; Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C- terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing e [...]	0.583
PDCD2L	ZNF277	ENSP00000246535	ENSP00000354501	Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.	Zinc finger protein 277; May be involved in transcriptional regulation; Belongs to the ZNF277 family.	0.608
PRMT3	PDCD2L	ENSP00000331879	ENSP00000246535	Protein arginine N-methyltransferase 3; Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.	Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.	0.998
PRMT3	RPS2	ENSP00000331879	ENSP00000341885	Protein arginine N-methyltransferase 3; Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.	Ribosomal protein S2.	0.999
PRMT3	ZNF277	ENSP00000331879	ENSP00000354501	Protein arginine N-methyltransferase 3; Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.	Zinc finger protein 277; May be involved in transcriptional regulation; Belongs to the ZNF277 family.	0.453

page 1 of 2

Server load: low (20%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About