node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IVL | KRT13 | ENSP00000357753 | ENSP00000246635 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Keratin, type I cytoskeletal 13; Keratin 13. | 0.633 |
IVL | KRT16 | ENSP00000357753 | ENSP00000301653 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance; Belongs to the intermediate filament family. | 0.677 |
IVL | KRT4 | ENSP00000357753 | ENSP00000448220 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family. | 0.565 |
IVL | KRT6A | ENSP00000357753 | ENSP00000369317 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Keratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Belongs to the intermediate filament family. | 0.404 |
IVL | SPRR3 | ENSP00000357753 | ENSP00000330391 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes. | 0.943 |
KRT13 | IVL | ENSP00000246635 | ENSP00000357753 | Keratin, type I cytoskeletal 13; Keratin 13. | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | 0.633 |
KRT13 | KRT15 | ENSP00000246635 | ENSP00000377546 | Keratin, type I cytoskeletal 13; Keratin 13. | Keratin, type I cytoskeletal 15; Keratin 15. | 0.676 |
KRT13 | KRT16 | ENSP00000246635 | ENSP00000301653 | Keratin, type I cytoskeletal 13; Keratin 13. | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance; Belongs to the intermediate filament family. | 0.596 |
KRT13 | KRT19 | ENSP00000246635 | ENSP00000355124 | Keratin, type I cytoskeletal 13; Keratin 13. | Keratin, type I cytoskeletal 19; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle; Belongs to the intermediate filament family. | 0.658 |
KRT13 | KRT20 | ENSP00000246635 | ENSP00000167588 | Keratin, type I cytoskeletal 13; Keratin 13. | Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). | 0.624 |
KRT13 | KRT4 | ENSP00000246635 | ENSP00000448220 | Keratin, type I cytoskeletal 13; Keratin 13. | Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family. | 0.986 |
KRT13 | KRT6A | ENSP00000246635 | ENSP00000369317 | Keratin, type I cytoskeletal 13; Keratin 13. | Keratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Belongs to the intermediate filament family. | 0.900 |
KRT13 | MMAA | ENSP00000246635 | ENSP00000497008 | Keratin, type I cytoskeletal 13; Keratin 13. | Methylmalonic aciduria type A protein, mitochondrial; GTPase, binds and hydrolyzes GTP. Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis. Functions as a G- protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) and reactivation of the enzyme during catalysis. | 0.633 |
KRT13 | PTPN14 | ENSP00000246635 | ENSP00000355923 | Keratin, type I cytoskeletal 13; Keratin 13. | Tyrosine-protein phosphatase non-receptor type 14; Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. Belongs to the protein-tyrosine phosphata [...] | 0.604 |
KRT13 | SPRR3 | ENSP00000246635 | ENSP00000330391 | Keratin, type I cytoskeletal 13; Keratin 13. | Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes. | 0.759 |
KRT15 | KRT13 | ENSP00000377546 | ENSP00000246635 | Keratin, type I cytoskeletal 15; Keratin 15. | Keratin, type I cytoskeletal 13; Keratin 13. | 0.676 |
KRT15 | KRT16 | ENSP00000377546 | ENSP00000301653 | Keratin, type I cytoskeletal 15; Keratin 15. | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance; Belongs to the intermediate filament family. | 0.621 |
KRT15 | KRT19 | ENSP00000377546 | ENSP00000355124 | Keratin, type I cytoskeletal 15; Keratin 15. | Keratin, type I cytoskeletal 19; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle; Belongs to the intermediate filament family. | 0.570 |
KRT15 | KRT20 | ENSP00000377546 | ENSP00000167588 | Keratin, type I cytoskeletal 15; Keratin 15. | Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). | 0.577 |
KRT15 | KRT4 | ENSP00000377546 | ENSP00000448220 | Keratin, type I cytoskeletal 15; Keratin 15. | Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family. | 0.593 |