node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTAG1B | CTAG2 | ENSP00000332602 | ENSP00000247306 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | 0.868 |
CTAG1B | MAGEA1 | ENSP00000332602 | ENSP00000349085 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.910 |
CTAG1B | MAGEA10 | ENSP00000332602 | ENSP00000244096 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 10; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. | 0.785 |
CTAG1B | MAGEA2 | ENSP00000332602 | ENSP00000485541 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | MAGE family member A2. | 0.828 |
CTAG1B | MAGEA2B | ENSP00000332602 | ENSP00000333487 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 2; Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal d [...] | 0.819 |
CTAG1B | MAGEA3 | ENSP00000332602 | ENSP00000473093 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.974 |
CTAG1B | MAGEA4 | ENSP00000332602 | ENSP00000353379 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. | 0.946 |
CTAG1B | MAGEA6 | ENSP00000332602 | ENSP00000480637 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 6; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. | 0.864 |
CTAG1B | MAGEC1 | ENSP00000332602 | ENSP00000285879 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen C1; MAGE family member C1. | 0.842 |
CTAG1B | SSX2 | ENSP00000332602 | ENSP00000338796 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | SSX family member 2. | 0.814 |
CTAG2 | CTAG1B | ENSP00000247306 | ENSP00000332602 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | 0.868 |
CTAG2 | MAGEA1 | ENSP00000247306 | ENSP00000349085 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.845 |
CTAG2 | MAGEA10 | ENSP00000247306 | ENSP00000244096 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 10; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. | 0.761 |
CTAG2 | MAGEA2 | ENSP00000247306 | ENSP00000485541 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | MAGE family member A2. | 0.794 |
CTAG2 | MAGEA2B | ENSP00000247306 | ENSP00000333487 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 2; Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal d [...] | 0.796 |
CTAG2 | MAGEA3 | ENSP00000247306 | ENSP00000473093 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.897 |
CTAG2 | MAGEA4 | ENSP00000247306 | ENSP00000353379 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. | 0.924 |
CTAG2 | MAGEA6 | ENSP00000247306 | ENSP00000480637 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 6; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. | 0.878 |
CTAG2 | MAGEC1 | ENSP00000247306 | ENSP00000285879 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen C1; MAGE family member C1. | 0.723 |
CTAG2 | SSX2 | ENSP00000247306 | ENSP00000338796 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | SSX family member 2. | 0.709 |