node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APOL1 | APOL2 | ENSP00000317674 | ENSP00000249066 | Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | 0.507 |
APOL1 | CHRM4 | ENSP00000317674 | ENSP00000409378 | Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. | Muscarinic acetylcholine receptor M4; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily. | 0.424 |
APOL1 | COMT | ENSP00000317674 | ENSP00000354511 | Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | 0.673 |
APOL1 | LOC102724788 | ENSP00000317674 | ENSP00000481127 | Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family. | 0.424 |
APOL1 | PRODH | ENSP00000317674 | ENSP00000349577 | Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. | 0.424 |
APOL2 | APOL1 | ENSP00000249066 | ENSP00000317674 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. | 0.507 |
APOL2 | CGB7 | ENSP00000249066 | ENSP00000470813 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Choriogonadotropin subunit beta 7; Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role for pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. | 0.524 |
APOL2 | CHRM4 | ENSP00000249066 | ENSP00000409378 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Muscarinic acetylcholine receptor M4; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily. | 0.489 |
APOL2 | COMT | ENSP00000249066 | ENSP00000354511 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | 0.673 |
APOL2 | GBP5 | ENSP00000249066 | ENSP00000359488 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Guanylate-binding protein 5; As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | 0.499 |
APOL2 | LOC102724788 | ENSP00000249066 | ENSP00000481127 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family. | 0.489 |
APOL2 | PLAAT2 | ENSP00000249066 | ENSP00000255695 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Phospholipase A and acyltransferase 2; Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. For most substrates, PLA1 activity is much higher than PLA2 activity. Shows O- acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group a [...] | 0.467 |
APOL2 | PRODH | ENSP00000249066 | ENSP00000349577 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. | 0.470 |
APOL2 | PSG9 | ENSP00000249066 | ENSP00000270077 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Pregnancy specific beta-1-glycoprotein 9. | 0.545 |
APOL2 | SNRPB2 | ENSP00000249066 | ENSP00000246071 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | U2 small nuclear ribonucleoprotein B'; Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA. | 0.516 |
CGB7 | APOL2 | ENSP00000470813 | ENSP00000249066 | Choriogonadotropin subunit beta 7; Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role for pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | 0.524 |
CGB7 | SNRPB2 | ENSP00000470813 | ENSP00000246071 | Choriogonadotropin subunit beta 7; Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role for pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. | U2 small nuclear ribonucleoprotein B'; Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA. | 0.568 |
CHRM4 | APOL1 | ENSP00000409378 | ENSP00000317674 | Muscarinic acetylcholine receptor M4; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily. | Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. | 0.424 |
CHRM4 | APOL2 | ENSP00000409378 | ENSP00000249066 | Muscarinic acetylcholine receptor M4; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily. | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | 0.489 |
COMT | APOL1 | ENSP00000354511 | ENSP00000317674 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. | 0.673 |