| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APBB2 | APOL2 | ENSP00000427211 | ENSP00000249066 | Amyloid-beta A4 precursor protein-binding family B member 2; May modulate the internalization of amyloid-beta precursor protein. | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | 0.498 |
| APOL1 | APOL2 | ENSP00000317674 | ENSP00000249066 | Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | 0.529 |
| APOL1 | CHRM4 | ENSP00000317674 | ENSP00000409378 | Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. | Muscarinic acetylcholine receptor M4; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily. | 0.427 |
| APOL1 | COMT | ENSP00000317674 | ENSP00000354511 | Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | 0.718 |
| APOL1 | LOC102724788 | ENSP00000317674 | ENSP00000481127 | Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family. | 0.432 |
| APOL1 | PRODH | ENSP00000317674 | ENSP00000349577 | Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. | 0.427 |
| APOL2 | APBB2 | ENSP00000249066 | ENSP00000427211 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Amyloid-beta A4 precursor protein-binding family B member 2; May modulate the internalization of amyloid-beta precursor protein. | 0.498 |
| APOL2 | APOL1 | ENSP00000249066 | ENSP00000317674 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. | 0.529 |
| APOL2 | CHRM4 | ENSP00000249066 | ENSP00000409378 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Muscarinic acetylcholine receptor M4; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily. | 0.505 |
| APOL2 | COMT | ENSP00000249066 | ENSP00000354511 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | 0.674 |
| APOL2 | GBP5 | ENSP00000249066 | ENSP00000359488 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Guanylate-binding protein 5; As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | 0.598 |
| APOL2 | LOC102724788 | ENSP00000249066 | ENSP00000481127 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family. | 0.494 |
| APOL2 | PRODH | ENSP00000249066 | ENSP00000349577 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. | 0.497 |
| APOL2 | PSG9 | ENSP00000249066 | ENSP00000270077 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Pregnancy specific beta-1-glycoprotein 9. | 0.679 |
| APOL2 | SNRPB2 | ENSP00000249066 | ENSP00000246071 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | U2 small nuclear ribonucleoprotein B'; Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA. | 0.505 |
| APOL2 | UBL4A | ENSP00000249066 | ENSP00000358674 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Ubiquitin-like protein 4A; As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthe [...] | 0.617 |
| CHRM4 | APOL1 | ENSP00000409378 | ENSP00000317674 | Muscarinic acetylcholine receptor M4; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily. | Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. | 0.427 |
| CHRM4 | APOL2 | ENSP00000409378 | ENSP00000249066 | Muscarinic acetylcholine receptor M4; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily. | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | 0.505 |
| COMT | APOL1 | ENSP00000354511 | ENSP00000317674 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. | 0.718 |
| COMT | APOL2 | ENSP00000354511 | ENSP00000249066 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | 0.674 |
