STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF221Zinc finger protein 221; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (617 aa)    
Predicted Functional Partners:
ZNF225
Zinc finger protein 225; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
  
  
0.532
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]
   
 0.522
OR11A1
Olfactory receptor 11A1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.507
OR10J1
Olfactory receptor 10J1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.507
ZSWIM1
Zinc finger SWIM-type containing 1.
    
 
 0.494
PRDM10
PR domain zinc finger protein 10; May be involved in transcriptional regulation.
      
0.430
ZNF284
Zinc finger protein 284; May be involved in transcriptional regulation.
  
  
0.429
CARD19
Caspase recruitment domain-containing protein 19; Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.
      
 0.418
C19orf53
Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy.
      
 0.406
NECAB1
N-terminal EF-hand calcium binding protein 1.
    
 
 0.405
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.