| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARL3 | C20orf194 | ENSP00000260746 | ENSP00000252032 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] | Uncharacterized protein C20orf194; May act as an effector for ARL3. | 0.706 |
| C20orf194 | ARL3 | ENSP00000252032 | ENSP00000260746 | Uncharacterized protein C20orf194; May act as an effector for ARL3. | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] | 0.706 |
| C20orf194 | DNAL4 | ENSP00000252032 | ENSP00000216068 | Uncharacterized protein C20orf194; May act as an effector for ARL3. | Dynein light chain 4, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity). | 0.489 |
| C20orf194 | DYNLT1 | ENSP00000252032 | ENSP00000356056 | Uncharacterized protein C20orf194; May act as an effector for ARL3. | Dynein light chain Tctex-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein. (Microbial infection) Is involved in intrac [...] | 0.496 |
| C20orf194 | DYNLT3 | ENSP00000252032 | ENSP00000367841 | Uncharacterized protein C20orf194; May act as an effector for ARL3. | Dynein light chain Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity); Belongs to the dynein light chain Tctex-type family. | 0.525 |
| C20orf194 | FEZ2 | ENSP00000252032 | ENSP00000368547 | Uncharacterized protein C20orf194; May act as an effector for ARL3. | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation. | 0.583 |
| C20orf194 | ITPA | ENSP00000252032 | ENSP00000369456 | Uncharacterized protein C20orf194; May act as an effector for ARL3. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.510 |
| C20orf194 | SENP7 | ENSP00000252032 | ENSP00000377655 | Uncharacterized protein C20orf194; May act as an effector for ARL3. | Sentrin-specific protease 7; Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms. | 0.495 |
| C20orf194 | TBC1D19 | ENSP00000252032 | ENSP00000264866 | Uncharacterized protein C20orf194; May act as an effector for ARL3. | TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s). | 0.616 |
| C20orf194 | TTBK2 | ENSP00000252032 | ENSP00000267890 | Uncharacterized protein C20orf194; May act as an effector for ARL3. | Tau-tubulin kinase 2; Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. | 0.565 |
| C20orf194 | WDR63 | ENSP00000252032 | ENSP00000294664 | Uncharacterized protein C20orf194; May act as an effector for ARL3. | WD repeat-containing protein 63. | 0.494 |
| DNAL4 | C20orf194 | ENSP00000216068 | ENSP00000252032 | Dynein light chain 4, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity). | Uncharacterized protein C20orf194; May act as an effector for ARL3. | 0.489 |
| DNAL4 | DYNLT1 | ENSP00000216068 | ENSP00000356056 | Dynein light chain 4, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity). | Dynein light chain Tctex-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein. (Microbial infection) Is involved in intrac [...] | 0.782 |
| DNAL4 | DYNLT3 | ENSP00000216068 | ENSP00000367841 | Dynein light chain 4, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity). | Dynein light chain Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity); Belongs to the dynein light chain Tctex-type family. | 0.761 |
| DNAL4 | WDR63 | ENSP00000216068 | ENSP00000294664 | Dynein light chain 4, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity). | WD repeat-containing protein 63. | 0.537 |
| DYNLT1 | C20orf194 | ENSP00000356056 | ENSP00000252032 | Dynein light chain Tctex-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein. (Microbial infection) Is involved in intrac [...] | Uncharacterized protein C20orf194; May act as an effector for ARL3. | 0.496 |
| DYNLT1 | DNAL4 | ENSP00000356056 | ENSP00000216068 | Dynein light chain Tctex-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein. (Microbial infection) Is involved in intrac [...] | Dynein light chain 4, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity). | 0.782 |
| DYNLT1 | DYNLT3 | ENSP00000356056 | ENSP00000367841 | Dynein light chain Tctex-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein. (Microbial infection) Is involved in intrac [...] | Dynein light chain Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity); Belongs to the dynein light chain Tctex-type family. | 0.860 |
| DYNLT1 | WDR63 | ENSP00000356056 | ENSP00000294664 | Dynein light chain Tctex-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein. (Microbial infection) Is involved in intrac [...] | WD repeat-containing protein 63. | 0.523 |
| DYNLT3 | C20orf194 | ENSP00000367841 | ENSP00000252032 | Dynein light chain Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity); Belongs to the dynein light chain Tctex-type family. | Uncharacterized protein C20orf194; May act as an effector for ARL3. | 0.525 |