STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZKSCAN3Zinc finger protein with KRAB and SCAN domains 3; Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas. (538 aa)    
Predicted Functional Partners:
ZNF396
Zinc finger protein 396; Isoform 1 and isoform 2 act as DNA-dependent transcriptional repressors.
  
  
0.862
ZSCAN32
Zinc finger and SCAN domain-containing protein 32; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
  
 
0.849
ZNF397
Zinc finger protein 397; Isoform 3 acts as a DNA-dependent transcriptional repressor.
  
  
0.840
ZKSCAN4
Zinc finger protein with KRAB and SCAN domains 4; May be involved in the transcriptional activation of MDM2 and EP300 genes; Belongs to the krueppel C2H2-type zinc-finger protein family.
  
 
0.833
ITGB4
Integrin beta-4; Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.
      
 0.830
PGBD1
piggyBac transposable element derived 1.
   
 
0.828
ZSCAN20
Zinc finger and SCAN domain-containing protein 20; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
  
 
0.815
ZNF24
Zinc finger protein 24; Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro; Belongs to the krueppel C2H2-type zinc-finger protein family.
  
 
 
0.794
ZNF232
Zinc finger protein 232; May be involved in transcriptional regulation.
   
  
0.768
ZNF444
Zinc finger protein 444; Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter; Belongs to the krueppel C2H2-type zinc-finger protein family.
  
  
0.748
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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