STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRT75Keratin, type II cytoskeletal 75; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle. (551 aa)    
Predicted Functional Partners:
KRT34
Keratin, type I cuticular Ha4; Keratin 34.
  
 
0.717
RSPH14
Radial spoke head 14 homolog; Belongs to the flagellar radial spoke RSP14 family.
    
 
 0.630
NUP62
Nuclear pore glycoprotein p62; Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown.
    
 
 0.625
KRT6B
Keratin, type II cytoskeletal 6B; Keratin 6B; Belongs to the intermediate filament family.
  
 
0.555
KRT82
Keratin, type II cuticular Hb2; Keratin 82; Belongs to the intermediate filament family.
  
 
0.523
KRT3
Keratin, type II cytoskeletal 3; Keratin 3; Belongs to the intermediate filament family.
  
0.520
KRT83
Keratin, type II cuticular Hb3; Keratin 83; Belongs to the intermediate filament family.
  
0.518
KRT76
Keratin, type II cytoskeletal 2 oral; Probably contributes to terminal cornification. Belongs to the intermediate filament family.
  
0.514
KRT71
Keratin, type II cytoskeletal 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle.
  
0.511
KRT6A
Keratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Belongs to the intermediate filament family.
  
 
0.505
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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