node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CABLES2 | PLAGL2 | ENSP00000279101 | ENSP00000246229 | CDK5 and ABL1 enzyme substrate 2; Unknown. Probably involved in G1-S cell cycle transition; Belongs to the cyclin family. | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.454 |
CABLES2 | RBBP8NL | ENSP00000279101 | ENSP00000252998 | CDK5 and ABL1 enzyme substrate 2; Unknown. Probably involved in G1-S cell cycle transition; Belongs to the cyclin family. | RBBP8 N-terminal-like protein; RBBP8 N-terminal like. | 0.643 |
KDF1 | OVOL2 | ENSP00000319179 | ENSP00000278780 | Keratinocyte differentiation factor 1; Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). | Transcription factor Ovo-like 2; Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. Important for the correct development of primordial germ cells in embryos (By similarity). | 0.466 |
KDF1 | RAB25 | ENSP00000319179 | ENSP00000354376 | Keratinocyte differentiation factor 1; Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). | Ras-related protein Rab-25; Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity). ECO:0000250|UniProtKB:P46629, ECO:0000250|UniProtKB:Q9WTL2,; Belongs to the small GTPase superfamily. Rab family. | 0.718 |
KDF1 | RBBP8NL | ENSP00000319179 | ENSP00000252998 | Keratinocyte differentiation factor 1; Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). | RBBP8 N-terminal-like protein; RBBP8 N-terminal like. | 0.478 |
KIF3B | PLAGL2 | ENSP00000364864 | ENSP00000246229 | Kinesin-like protein KIF3B, N-terminally processed; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity). | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.748 |
KIF3B | POFUT1 | ENSP00000364864 | ENSP00000364902 | Kinesin-like protein KIF3B, N-terminally processed; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity). | GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that ca [...] | 0.770 |
KIF3B | RBBP8NL | ENSP00000364864 | ENSP00000252998 | Kinesin-like protein KIF3B, N-terminally processed; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity). | RBBP8 N-terminal-like protein; RBBP8 N-terminal like. | 0.516 |
KIF3B | SOX15 | ENSP00000364864 | ENSP00000355354 | Kinesin-like protein KIF3B, N-terminally processed; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity). | Protein SOX-15; Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (By similarity). Acts as a transcriptional activator and repressor (By similarity). Binds synergistically with POU5F1 (OCT3/4) to gene promoters (By similarity). Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation (By similarity). Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG (By similarity). Involved in t [...] | 0.425 |
KIF3B | TM9SF4 | ENSP00000364864 | ENSP00000381104 | Kinesin-like protein KIF3B, N-terminally processed; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity). | Transmembrane 9 superfamily member 4; Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells. Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the [...] | 0.584 |
OVOL2 | KDF1 | ENSP00000278780 | ENSP00000319179 | Transcription factor Ovo-like 2; Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. Important for the correct development of primordial germ cells in embryos (By similarity). | Keratinocyte differentiation factor 1; Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). | 0.466 |
OVOL2 | RAB25 | ENSP00000278780 | ENSP00000354376 | Transcription factor Ovo-like 2; Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. Important for the correct development of primordial germ cells in embryos (By similarity). | Ras-related protein Rab-25; Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity). ECO:0000250|UniProtKB:P46629, ECO:0000250|UniProtKB:Q9WTL2,; Belongs to the small GTPase superfamily. Rab family. | 0.455 |
OVOL2 | RBBP8NL | ENSP00000278780 | ENSP00000252998 | Transcription factor Ovo-like 2; Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. Important for the correct development of primordial germ cells in embryos (By similarity). | RBBP8 N-terminal-like protein; RBBP8 N-terminal like. | 0.499 |
PLAGL2 | CABLES2 | ENSP00000246229 | ENSP00000279101 | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Belongs to the krueppel C2H2-type zinc-finger protein family. | CDK5 and ABL1 enzyme substrate 2; Unknown. Probably involved in G1-S cell cycle transition; Belongs to the cyclin family. | 0.454 |
PLAGL2 | KIF3B | ENSP00000246229 | ENSP00000364864 | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Belongs to the krueppel C2H2-type zinc-finger protein family. | Kinesin-like protein KIF3B, N-terminally processed; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity). | 0.748 |
PLAGL2 | POFUT1 | ENSP00000246229 | ENSP00000364902 | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Belongs to the krueppel C2H2-type zinc-finger protein family. | GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that ca [...] | 0.804 |
PLAGL2 | RBBP8NL | ENSP00000246229 | ENSP00000252998 | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Belongs to the krueppel C2H2-type zinc-finger protein family. | RBBP8 N-terminal-like protein; RBBP8 N-terminal like. | 0.456 |
PLAGL2 | RCHY1 | ENSP00000246229 | ENSP00000321239 | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Belongs to the krueppel C2H2-type zinc-finger protein family. | RING finger and CHY zinc finger domain-containing protein 1; Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity. | 0.461 |
PLAGL2 | TM9SF4 | ENSP00000246229 | ENSP00000381104 | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transmembrane 9 superfamily member 4; Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells. Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the [...] | 0.717 |
POFUT1 | KIF3B | ENSP00000364902 | ENSP00000364864 | GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that ca [...] | Kinesin-like protein KIF3B, N-terminally processed; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity). | 0.770 |