node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNAJC27 | FPGT-TNNI3K | ENSP00000264711 | ENSP00000450895 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | FPGT-TNNI3K readthrough. | 0.627 |
DNAJC27 | GNPDA2 | ENSP00000264711 | ENSP00000295448 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Glucosamine-6-phosphate deaminase 2. | 0.618 |
DNAJC27 | MTIF3 | ENSP00000264711 | ENSP00000370508 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Translation initiation factor IF-3, mitochondrial; IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins. | 0.573 |
DNAJC27 | NUDT3 | ENSP00000264711 | ENSP00000476119 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Diphosphoinositol polyphosphate phosphohydrolase 1; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able t [...] | 0.588 |
DNAJC27 | POC5 | ENSP00000264711 | ENSP00000410216 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Centrosomal protein POC5; Essential for the assembly of the distal half of centrioles, required for centriole elongation; Belongs to the POC5 family. | 0.614 |
DNAJC27 | QPCTL | ENSP00000264711 | ENSP00000012049 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Glutaminyl-peptide cyclotransferase-like protein; Responsible for the biosynthesis of pyroglutamyl peptides. | 0.597 |
DNAJC27 | SEC16B | ENSP00000264711 | ENSP00000308339 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Protein transport protein Sec16B; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes ; Belongs to the SEC16 family. | 0.665 |
DNAJC27 | TMEM160 | ENSP00000264711 | ENSP00000253047 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Transmembrane protein 160. | 0.621 |
DNAJC27 | TNNI3K | ENSP00000264711 | ENSP00000322251 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Serine/threonine-protein kinase TNNI3K; May play a role in cardiac physiology. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | 0.617 |
DNAJC27 | ZNF608 | ENSP00000264711 | ENSP00000307746 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Zinc finger protein 608; Transcription factor, which represses ZNF609 transcription. | 0.606 |
FPGT-TNNI3K | DNAJC27 | ENSP00000450895 | ENSP00000264711 | FPGT-TNNI3K readthrough. | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | 0.627 |
FPGT-TNNI3K | GNPDA2 | ENSP00000450895 | ENSP00000295448 | FPGT-TNNI3K readthrough. | Glucosamine-6-phosphate deaminase 2. | 0.668 |
FPGT-TNNI3K | MTIF3 | ENSP00000450895 | ENSP00000370508 | FPGT-TNNI3K readthrough. | Translation initiation factor IF-3, mitochondrial; IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins. | 0.596 |
FPGT-TNNI3K | NUDT3 | ENSP00000450895 | ENSP00000476119 | FPGT-TNNI3K readthrough. | Diphosphoinositol polyphosphate phosphohydrolase 1; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able t [...] | 0.585 |
FPGT-TNNI3K | POC5 | ENSP00000450895 | ENSP00000410216 | FPGT-TNNI3K readthrough. | Centrosomal protein POC5; Essential for the assembly of the distal half of centrioles, required for centriole elongation; Belongs to the POC5 family. | 0.596 |
FPGT-TNNI3K | QPCTL | ENSP00000450895 | ENSP00000012049 | FPGT-TNNI3K readthrough. | Glutaminyl-peptide cyclotransferase-like protein; Responsible for the biosynthesis of pyroglutamyl peptides. | 0.620 |
FPGT-TNNI3K | SEC16B | ENSP00000450895 | ENSP00000308339 | FPGT-TNNI3K readthrough. | Protein transport protein Sec16B; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes ; Belongs to the SEC16 family. | 0.719 |
FPGT-TNNI3K | TMEM160 | ENSP00000450895 | ENSP00000253047 | FPGT-TNNI3K readthrough. | Transmembrane protein 160. | 0.599 |
FPGT-TNNI3K | TNNI3K | ENSP00000450895 | ENSP00000322251 | FPGT-TNNI3K readthrough. | Serine/threonine-protein kinase TNNI3K; May play a role in cardiac physiology. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | 0.902 |
FPGT-TNNI3K | ZNF608 | ENSP00000450895 | ENSP00000307746 | FPGT-TNNI3K readthrough. | Zinc finger protein 608; Transcription factor, which represses ZNF609 transcription. | 0.570 |