node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAALC | ZNF236 | ENSP00000312457 | ENSP00000322361 | BAALC binder of MAP3K1 and KLF4. | Zinc finger protein 236; May be involved in transcriptional regulation. | 0.565 |
CAPN15 | ZNF236 | ENSP00000219611 | ENSP00000322361 | Calpain-15; Calpain 15; Belongs to the peptidase C2 family. | Zinc finger protein 236; May be involved in transcriptional regulation. | 0.522 |
CAPN15 | ZNF594 | ENSP00000219611 | ENSP00000461032 | Calpain-15; Calpain 15; Belongs to the peptidase C2 family. | Zinc finger protein 594; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.573 |
CCAR2 | ZNF236 | ENSP00000310670 | ENSP00000322361 | Cell cycle and apoptosis regulator protein 2; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53- mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part [...] | Zinc finger protein 236; May be involved in transcriptional regulation. | 0.487 |
ERCC6 | MLLT3 | ENSP00000348089 | ENSP00000369695 | DNA excision repair protein ERCC-6; Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the sites of RNA polymerase II-b [...] | Protein AF-9; Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylate [...] | 0.913 |
ERCC6 | ZNF236 | ENSP00000348089 | ENSP00000322361 | DNA excision repair protein ERCC-6; Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the sites of RNA polymerase II-b [...] | Zinc finger protein 236; May be involved in transcriptional regulation. | 0.661 |
ERCC6L2 | ZNF236 | ENSP00000499371 | ENSP00000322361 | DNA excision repair protein ERCC-6-like 2; May be involved in early DNA damage response. | Zinc finger protein 236; May be involved in transcriptional regulation. | 0.498 |
GALR1 | ZNF236 | ENSP00000299727 | ENSP00000322361 | Galanin receptor type 1; Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity; Belongs to the G-protein coupled receptor 1 family. | Zinc finger protein 236; May be involved in transcriptional regulation. | 0.460 |
MLLT3 | ERCC6 | ENSP00000369695 | ENSP00000348089 | Protein AF-9; Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylate [...] | DNA excision repair protein ERCC-6; Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the sites of RNA polymerase II-b [...] | 0.913 |
MLLT3 | ZNF236 | ENSP00000369695 | ENSP00000322361 | Protein AF-9; Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylate [...] | Zinc finger protein 236; May be involved in transcriptional regulation. | 0.474 |
USF3 | ZNF236 | ENSP00000320794 | ENSP00000322361 | Basic helix-loop-helix domain-containing protein USF3; Involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties. | Zinc finger protein 236; May be involved in transcriptional regulation. | 0.457 |
ZNF236 | BAALC | ENSP00000322361 | ENSP00000312457 | Zinc finger protein 236; May be involved in transcriptional regulation. | BAALC binder of MAP3K1 and KLF4. | 0.565 |
ZNF236 | CAPN15 | ENSP00000322361 | ENSP00000219611 | Zinc finger protein 236; May be involved in transcriptional regulation. | Calpain-15; Calpain 15; Belongs to the peptidase C2 family. | 0.522 |
ZNF236 | CCAR2 | ENSP00000322361 | ENSP00000310670 | Zinc finger protein 236; May be involved in transcriptional regulation. | Cell cycle and apoptosis regulator protein 2; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53- mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part [...] | 0.487 |
ZNF236 | ERCC6 | ENSP00000322361 | ENSP00000348089 | Zinc finger protein 236; May be involved in transcriptional regulation. | DNA excision repair protein ERCC-6; Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the sites of RNA polymerase II-b [...] | 0.661 |
ZNF236 | ERCC6L2 | ENSP00000322361 | ENSP00000499371 | Zinc finger protein 236; May be involved in transcriptional regulation. | DNA excision repair protein ERCC-6-like 2; May be involved in early DNA damage response. | 0.498 |
ZNF236 | GALR1 | ENSP00000322361 | ENSP00000299727 | Zinc finger protein 236; May be involved in transcriptional regulation. | Galanin receptor type 1; Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity; Belongs to the G-protein coupled receptor 1 family. | 0.460 |
ZNF236 | MLLT3 | ENSP00000322361 | ENSP00000369695 | Zinc finger protein 236; May be involved in transcriptional regulation. | Protein AF-9; Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylate [...] | 0.474 |
ZNF236 | USF3 | ENSP00000322361 | ENSP00000320794 | Zinc finger protein 236; May be involved in transcriptional regulation. | Basic helix-loop-helix domain-containing protein USF3; Involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties. | 0.457 |
ZNF236 | ZNF407 | ENSP00000322361 | ENSP00000299687 | Zinc finger protein 236; May be involved in transcriptional regulation. | Zinc finger protein 407; May be involved in transcriptional regulation. | 0.819 |