STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PKDREJPolycystic kidney disease and receptor for egg jelly-related protein; May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm; Belongs to the polycystin family. (2253 aa)    
Predicted Functional Partners:
ZP3
Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
      
 0.939
CDPF1
Cysteine rich DPF motif domain containing 1.
 
    
 0.614
ZFAND4
Zinc finger AN1-type containing 4.
   
  
 0.597
C12orf40
Uncharacterized protein C12orf40; Chromosome 12 open reading frame 40.
      
 0.593
C9orf43
Uncharacterized protein C9orf43; Chromosome 9 open reading frame 43.
      
 0.574
FAM209A
Protein FAM209A; Family with sequence similarity 209 member A.
   
  
 0.568
ZAN
Zonadhesin; Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.
   
  
 0.567
C9orf131
Uncharacterized protein C9orf131; Chromosome 9 open reading frame 131.
    
 
 0.561
SPATA16
Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion.
   
  
 0.561
MAGEB16
Melanoma-associated antigen B16; MAGE family member B16.
    
 
 0.555
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.