node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASC1 | CCDC114 | ENSP00000379310 | ENSP00000318429 | Protein CASC1. | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | 0.768 |
CASC1 | DNAH1 | ENSP00000379310 | ENSP00000401514 | Protein CASC1. | Dynein heavy chain 1, axonemal; Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme ; Belongs to the dynein heavy chain family. | 0.770 |
CASC1 | DNAH2 | ENSP00000379310 | ENSP00000458355 | Protein CASC1. | Dynein heavy chain 2, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). | 0.782 |
CASC1 | DNAI1 | ENSP00000379310 | ENSP00000480538 | Protein CASC1. | Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family. | 0.620 |
CASC1 | DNAI2 | ENSP00000379310 | ENSP00000400252 | Protein CASC1. | Dynein intermediate chain 2, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family. | 0.769 |
CASC1 | DNAL1 | ENSP00000379310 | ENSP00000452037 | Protein CASC1. | Dynein light chain 1, axonemal; Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-rig [...] | 0.782 |
CASC1 | DNHD1 | ENSP00000379310 | ENSP00000254579 | Protein CASC1. | Dynein heavy chain domain 1. | 0.592 |
CASC1 | NME8 | ENSP00000379310 | ENSP00000199447 | Protein CASC1. | Thioredoxin domain-containing protein 3; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds. | 0.574 |
CASC1 | WDR63 | ENSP00000379310 | ENSP00000294664 | Protein CASC1. | WD repeat-containing protein 63. | 0.844 |
CASC1 | WDR78 | ENSP00000379310 | ENSP00000360065 | Protein CASC1. | WD repeat-containing protein 78. | 0.795 |
CCDC114 | CASC1 | ENSP00000318429 | ENSP00000379310 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Protein CASC1. | 0.768 |
CCDC114 | DNAH1 | ENSP00000318429 | ENSP00000401514 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Dynein heavy chain 1, axonemal; Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme ; Belongs to the dynein heavy chain family. | 0.931 |
CCDC114 | DNAH2 | ENSP00000318429 | ENSP00000458355 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Dynein heavy chain 2, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). | 0.839 |
CCDC114 | DNAI1 | ENSP00000318429 | ENSP00000480538 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family. | 0.938 |
CCDC114 | DNAI2 | ENSP00000318429 | ENSP00000400252 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Dynein intermediate chain 2, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family. | 0.963 |
CCDC114 | DNAL1 | ENSP00000318429 | ENSP00000452037 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Dynein light chain 1, axonemal; Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-rig [...] | 0.805 |
CCDC114 | DNHD1 | ENSP00000318429 | ENSP00000254579 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Dynein heavy chain domain 1. | 0.681 |
CCDC114 | NME8 | ENSP00000318429 | ENSP00000199447 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Thioredoxin domain-containing protein 3; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds. | 0.940 |
CCDC114 | WDR63 | ENSP00000318429 | ENSP00000294664 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | WD repeat-containing protein 63. | 0.828 |
CCDC114 | WDR78 | ENSP00000318429 | ENSP00000360065 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | WD repeat-containing protein 78. | 0.840 |