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PDE6A protein (human) - STRING interaction network
"PDE6A" - Phosphodiesterase 6A, cGMP-specific, rod, alpha in Homo sapiens
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PDE6APhosphodiesterase 6A, cGMP-specific, rod, alpha; This protein participates in processes of transmission and amplification of the visual signal (860 aa)    
Predicted Functional Partners:
PDE6G
Phosphodiesterase 6G, cGMP-specific, rod, gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones (87 aa)
     
  0.993
PDE6H
Phosphodiesterase 6H, cGMP-specific, cone, gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones (83 aa)
     
  0.986
CNGB1
Cyclic nucleotide gated channel beta 1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP (1251 aa)
     
  0.974
GUCY2D
Guanylate cyclase 2D, membrane (retina-specific); Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction (1103 aa)
     
  0.959
CNGA1
Cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors (759 aa)
     
 
  0.955
ADCY5
Adenylate cyclase 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed-15385642, PubMed-26206488, PubMed-24700542). Mediates signaling downstream of ADRB1 (PubMed-24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed-24740569) (1261 aa)
     
  0.953
ADCY2
Adenylate cyclase 2 (brain); Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed-15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity) (1091 aa)
     
  0.953
ADCY4
Adenylate cyclase 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (1077 aa)
     
  0.953
ADCY6
Adenylate cyclase 6; Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed-17916776, PubMed-17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed-17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and S [...] (1168 aa)
     
  0.953
ADCY8
Adenylate cyclase 8 (brain); This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity) (1251 aa)
     
  0.953
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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