node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCD4 | AREL1 | ENSP00000349396 | ENSP00000348714 | ATP-binding cassette sub-family D member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm. | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation. | 0.428 |
ABCD4 | VRTN | ENSP00000349396 | ENSP00000256362 | ATP-binding cassette sub-family D member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm. | Vertnin; Vertebrae development associated; Belongs to the vertnin family. | 0.650 |
AREL1 | ABCD4 | ENSP00000348714 | ENSP00000349396 | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation. | ATP-binding cassette sub-family D member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm. | 0.428 |
AREL1 | PROX2 | ENSP00000348714 | ENSP00000451223 | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation. | Prospero homeobox protein 2; Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity). Belongs to the Prospero homeodomain family. | 0.598 |
AREL1 | SYNDIG1L | ENSP00000348714 | ENSP00000331474 | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation. | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | 0.475 |
AREL1 | VRTN | ENSP00000348714 | ENSP00000256362 | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation. | Vertnin; Vertebrae development associated; Belongs to the vertnin family. | 0.621 |
C9orf72 | VRTN | ENSP00000482753 | ENSP00000256362 | Guanine nucleotide exchange C9orf72; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP- bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and modulating its protein kinase activity. Positivel [...] | Vertnin; Vertebrae development associated; Belongs to the vertnin family. | 0.591 |
NR6A1 | TDGF1 | ENSP00000420267 | ENSP00000296145 | Nuclear receptor subfamily 6 group A member 1; Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity). | Teratocarcinoma-derived growth factor 1; GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. | 0.848 |
NR6A1 | VRTN | ENSP00000420267 | ENSP00000256362 | Nuclear receptor subfamily 6 group A member 1; Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity). | Vertnin; Vertebrae development associated; Belongs to the vertnin family. | 0.646 |
PROX2 | AREL1 | ENSP00000451223 | ENSP00000348714 | Prospero homeobox protein 2; Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity). Belongs to the Prospero homeodomain family. | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation. | 0.598 |
PROX2 | SYNDIG1L | ENSP00000451223 | ENSP00000331474 | Prospero homeobox protein 2; Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity). Belongs to the Prospero homeodomain family. | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | 0.541 |
PROX2 | VRTN | ENSP00000451223 | ENSP00000256362 | Prospero homeobox protein 2; Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity). Belongs to the Prospero homeodomain family. | Vertnin; Vertebrae development associated; Belongs to the vertnin family. | 0.726 |
SALL1 | SALL3 | ENSP00000251020 | ENSP00000441823 | Sal-like protein 1; Transcriptional repressor involved in organogenesis. | Sal-like protein 3; Probable transcription factor. | 0.684 |
SALL1 | VRTN | ENSP00000251020 | ENSP00000256362 | Sal-like protein 1; Transcriptional repressor involved in organogenesis. | Vertnin; Vertebrae development associated; Belongs to the vertnin family. | 0.513 |
SALL3 | SALL1 | ENSP00000441823 | ENSP00000251020 | Sal-like protein 3; Probable transcription factor. | Sal-like protein 1; Transcriptional repressor involved in organogenesis. | 0.684 |
SALL3 | VRTN | ENSP00000441823 | ENSP00000256362 | Sal-like protein 3; Probable transcription factor. | Vertnin; Vertebrae development associated; Belongs to the vertnin family. | 0.641 |
SYNDIG1L | AREL1 | ENSP00000331474 | ENSP00000348714 | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation. | 0.475 |
SYNDIG1L | PROX2 | ENSP00000331474 | ENSP00000451223 | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | Prospero homeobox protein 2; Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity). Belongs to the Prospero homeodomain family. | 0.541 |
SYNDIG1L | VRTN | ENSP00000331474 | ENSP00000256362 | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | Vertnin; Vertebrae development associated; Belongs to the vertnin family. | 0.714 |
TDGF1 | NR6A1 | ENSP00000296145 | ENSP00000420267 | Teratocarcinoma-derived growth factor 1; GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. | Nuclear receptor subfamily 6 group A member 1; Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity). | 0.848 |