node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CARS1 | CARS2 | ENSP00000369897 | ENSP00000257347 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.913 |
CARS1 | CBS | ENSP00000369897 | ENSP00000381231 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Cystathionine beta-synthase-like protein; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | 0.673 |
CARS1 | CBSL | ENSP00000369897 | ENSP00000485527 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Cystathionine beta-synthase like. | 0.565 |
CARS1 | IARS1 | ENSP00000369897 | ENSP00000364794 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Isoleucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. | 0.905 |
CARS1 | IARS2 | ENSP00000369897 | ENSP00000355889 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Isoleucine--tRNA ligase, mitochondrial; isoleucyl-tRNA synthetase 2, mitochondrial. | 0.901 |
CARS1 | LARS1 | ENSP00000369897 | ENSP00000377954 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Leucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs. | 0.950 |
CARS1 | LARS2 | ENSP00000369897 | ENSP00000498867 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Probable leucine--tRNA ligase, mitochondrial; leucyl-tRNA synthetase 2, mitochondrial. | 0.923 |
CARS1 | PARS2 | ENSP00000369897 | ENSP00000360327 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Probable proline--tRNA ligase, mitochondrial; prolyl-tRNA synthetase 2, mitochondrial. | 0.900 |
CARS1 | RARS2 | ENSP00000369897 | ENSP00000358549 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Probable arginine--tRNA ligase, mitochondrial; arginyl-tRNA synthetase 2, mitochondrial. | 0.859 |
CARS1 | VARS1 | ENSP00000369897 | ENSP00000364815 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Valine--tRNA ligase; valyl-tRNA synthetase 1; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.872 |
CARS2 | CARS1 | ENSP00000257347 | ENSP00000369897 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | 0.913 |
CARS2 | CBS | ENSP00000257347 | ENSP00000381231 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Cystathionine beta-synthase-like protein; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | 0.932 |
CARS2 | CBSL | ENSP00000257347 | ENSP00000485527 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Cystathionine beta-synthase like. | 0.928 |
CARS2 | IARS1 | ENSP00000257347 | ENSP00000364794 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Isoleucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. | 0.902 |
CARS2 | IARS2 | ENSP00000257347 | ENSP00000355889 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Isoleucine--tRNA ligase, mitochondrial; isoleucyl-tRNA synthetase 2, mitochondrial. | 0.944 |
CARS2 | LARS1 | ENSP00000257347 | ENSP00000377954 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Leucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs. | 0.935 |
CARS2 | LARS2 | ENSP00000257347 | ENSP00000498867 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Probable leucine--tRNA ligase, mitochondrial; leucyl-tRNA synthetase 2, mitochondrial. | 0.928 |
CARS2 | PARS2 | ENSP00000257347 | ENSP00000360327 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Probable proline--tRNA ligase, mitochondrial; prolyl-tRNA synthetase 2, mitochondrial. | 0.909 |
CARS2 | RARS2 | ENSP00000257347 | ENSP00000358549 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Probable arginine--tRNA ligase, mitochondrial; arginyl-tRNA synthetase 2, mitochondrial. | 0.889 |
CARS2 | VARS1 | ENSP00000257347 | ENSP00000364815 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Valine--tRNA ligase; valyl-tRNA synthetase 1; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.892 |