FAM189A2 protein (human) - STRING interaction network

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD13D	FAM189A2	ENSP00000427130	ENSP00000304435	Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.	Protein FAM189A2; Family with sequence similarity 189 member A2.	0.795
ANKRD13D	FAM189B	ENSP00000427130	ENSP00000354958	Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.	Protein FAM189B; Family with sequence similarity 189 member B.	0.805
FAM189A2	ANKRD13D	ENSP00000304435	ENSP00000427130	Protein FAM189A2; Family with sequence similarity 189 member A2.	Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.	0.795
FAM189A2	FAM189B	ENSP00000304435	ENSP00000354958	Protein FAM189A2; Family with sequence similarity 189 member A2.	Protein FAM189B; Family with sequence similarity 189 member B.	0.881
FAM189A2	HECW2	ENSP00000304435	ENSP00000260983	Protein FAM189A2; Family with sequence similarity 189 member A2.	E3 ubiquitin-protein ligase HECW2; E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Involved in the regulation of mitotic metaphase/anaphase transition.	0.814
FAM189A2	ITCH	ENSP00000304435	ENSP00000499786	Protein FAM189A2; Family with sequence similarity 189 member A2.	E3 ubiquitin-protein ligase Itchy homolog; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. Involved in the control of inflammatory signaling pathways. Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after [...]	0.880
FAM189A2	NEDD4L	ENSP00000304435	ENSP00000383199	Protein FAM189A2; Family with sequence similarity 189 member A2.	E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5. Promotes ubiquitination and [...]	0.844
FAM189A2	PCNX3	ENSP00000304435	ENSP00000347931	Protein FAM189A2; Family with sequence similarity 189 member A2.	Pecanex-like protein 3; Pecanex 3; Belongs to the pecanex family.	0.818
FAM189A2	TJP2	ENSP00000304435	ENSP00000438262	Protein FAM189A2; Family with sequence similarity 189 member A2.	Tight junction protein ZO-2; Plays a role in tight junctions and adherens junctions.	0.853
FAM189A2	TSPO	ENSP00000304435	ENSP00000379563	Protein FAM189A2; Family with sequence similarity 189 member A2.	Translocator protein; Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism , but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral- type benzodiazepine receptor; can also bind isoquinoline carboxamides ; Belongs to the TspO/BZRP family.	0.833
FAM189A2	WWP1	ENSP00000304435	ENSP00000427793	Protein FAM189A2; Family with sequence similarity 189 member A2.	NEDD4-like E3 ubiquitin-protein ligase WWP1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to [...]	0.931
FAM189A2	WWP2	ENSP00000304435	ENSP00000352069	Protein FAM189A2; Family with sequence similarity 189 member A2.	NEDD4-like E3 ubiquitin-protein ligase WWP2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T- cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiqu [...]	0.972
FAM189B	ANKRD13D	ENSP00000354958	ENSP00000427130	Protein FAM189B; Family with sequence similarity 189 member B.	Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.	0.805
FAM189B	FAM189A2	ENSP00000354958	ENSP00000304435	Protein FAM189B; Family with sequence similarity 189 member B.	Protein FAM189A2; Family with sequence similarity 189 member A2.	0.881
FAM189B	HECW2	ENSP00000354958	ENSP00000260983	Protein FAM189B; Family with sequence similarity 189 member B.	E3 ubiquitin-protein ligase HECW2; E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Involved in the regulation of mitotic metaphase/anaphase transition.	0.868
FAM189B	ITCH	ENSP00000354958	ENSP00000499786	Protein FAM189B; Family with sequence similarity 189 member B.	E3 ubiquitin-protein ligase Itchy homolog; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. Involved in the control of inflammatory signaling pathways. Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after [...]	0.857
FAM189B	NEDD4L	ENSP00000354958	ENSP00000383199	Protein FAM189B; Family with sequence similarity 189 member B.	E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5. Promotes ubiquitination and [...]	0.842
FAM189B	WWP1	ENSP00000354958	ENSP00000427793	Protein FAM189B; Family with sequence similarity 189 member B.	NEDD4-like E3 ubiquitin-protein ligase WWP1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to [...]	0.844
FAM189B	WWP2	ENSP00000354958	ENSP00000352069	Protein FAM189B; Family with sequence similarity 189 member B.	NEDD4-like E3 ubiquitin-protein ligase WWP2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T- cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiqu [...]	0.493
HECW2	FAM189A2	ENSP00000260983	ENSP00000304435	E3 ubiquitin-protein ligase HECW2; E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Involved in the regulation of mitotic metaphase/anaphase transition.	Protein FAM189A2; Family with sequence similarity 189 member A2.	0.814