node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C6orf201 | RNFT2 | ENSP00000420610 | ENSP00000257575 | Uncharacterized protein C6orf201; Chromosome 6 open reading frame 201. | Ring finger protein, transmembrane 2. | 0.544 |
DZANK1 | RNFT2 | ENSP00000262547 | ENSP00000257575 | Double zinc ribbon and ankyrin repeat domains 1. | Ring finger protein, transmembrane 2. | 0.471 |
FBXW8 | RNFT2 | ENSP00000498999 | ENSP00000257575 | F-box/WD repeat-containing protein 8; Substrate-recognition component of a Cul7-RING ubiquitin- protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7- RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 [...] | Ring finger protein, transmembrane 2. | 0.429 |
GPRIN1 | RNFT2 | ENSP00000305839 | ENSP00000257575 | G protein-regulated inducer of neurite outgrowth 1; May be involved in neurite outgrowth. | Ring finger protein, transmembrane 2. | 0.433 |
PRR18 | RNFT2 | ENSP00000319590 | ENSP00000257575 | Proline-rich protein 18; Proline rich 18. | Ring finger protein, transmembrane 2. | 0.441 |
RNF130 | RNF183 | ENSP00000430237 | ENSP00000419454 | E3 ubiquitin-protein ligase RNF130; May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase. | E3 ubiquitin-protein ligase RNF183; Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling. | 0.430 |
RNF130 | RNF223 | ENSP00000430237 | ENSP00000410533 | E3 ubiquitin-protein ligase RNF130; May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase. | Ring finger protein 223. | 0.495 |
RNF130 | RNFT2 | ENSP00000430237 | ENSP00000257575 | E3 ubiquitin-protein ligase RNF130; May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase. | Ring finger protein, transmembrane 2. | 0.439 |
RNF144A | RNF183 | ENSP00000321330 | ENSP00000419454 | E3 ubiquitin-protein ligase RNF144A; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC; Belongs to the RBR family. RNF144 subfamily. | E3 ubiquitin-protein ligase RNF183; Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling. | 0.409 |
RNF144A | RNF223 | ENSP00000321330 | ENSP00000410533 | E3 ubiquitin-protein ligase RNF144A; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC; Belongs to the RBR family. RNF144 subfamily. | Ring finger protein 223. | 0.483 |
RNF144A | RNFT2 | ENSP00000321330 | ENSP00000257575 | E3 ubiquitin-protein ligase RNF144A; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC; Belongs to the RBR family. RNF144 subfamily. | Ring finger protein, transmembrane 2. | 0.431 |
RNF144A | TMEM129 | ENSP00000321330 | ENSP00000372394 | E3 ubiquitin-protein ligase RNF144A; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC; Belongs to the RBR family. RNF144 subfamily. | E3 ubiquitin-protein ligase TM129; E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation. | 0.400 |
RNF183 | RNF130 | ENSP00000419454 | ENSP00000430237 | E3 ubiquitin-protein ligase RNF183; Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling. | E3 ubiquitin-protein ligase RNF130; May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase. | 0.430 |
RNF183 | RNF144A | ENSP00000419454 | ENSP00000321330 | E3 ubiquitin-protein ligase RNF183; Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling. | E3 ubiquitin-protein ligase RNF144A; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC; Belongs to the RBR family. RNF144 subfamily. | 0.409 |
RNF183 | RNFT2 | ENSP00000419454 | ENSP00000257575 | E3 ubiquitin-protein ligase RNF183; Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling. | Ring finger protein, transmembrane 2. | 0.467 |
RNF223 | RNF130 | ENSP00000410533 | ENSP00000430237 | Ring finger protein 223. | E3 ubiquitin-protein ligase RNF130; May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase. | 0.495 |
RNF223 | RNF144A | ENSP00000410533 | ENSP00000321330 | Ring finger protein 223. | E3 ubiquitin-protein ligase RNF144A; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC; Belongs to the RBR family. RNF144 subfamily. | 0.483 |
RNF223 | RNFT2 | ENSP00000410533 | ENSP00000257575 | Ring finger protein 223. | Ring finger protein, transmembrane 2. | 0.567 |
RNF223 | TMEM129 | ENSP00000410533 | ENSP00000372394 | Ring finger protein 223. | E3 ubiquitin-protein ligase TM129; E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation. | 0.504 |
RNFT2 | C6orf201 | ENSP00000257575 | ENSP00000420610 | Ring finger protein, transmembrane 2. | Uncharacterized protein C6orf201; Chromosome 6 open reading frame 201. | 0.544 |