Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
KRT84Keratin, type II cuticular Hb4; Keratin 84. (600 aa)    
Predicted Functional Partners:
KRT76
Keratin, type II cytoskeletal 2 oral; Probably contributes to terminal cornification. Belongs to the intermediate filament family.
  
0.953
KRT79
Keratin, type II cytoskeletal 79; Keratin 79; Belongs to the intermediate filament family.
  
0.950
KRT3
Keratin, type II cytoskeletal 3; Keratin 3; Belongs to the intermediate filament family.
  
0.949
KRT75
Keratin, type II cytoskeletal 75; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle.
  
0.919
KRT7
Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). Belongs to the intermediate filament family.
  
0.880
KRT83
Keratin, type II cuticular Hb3; Keratin 83; Belongs to the intermediate filament family.
  
0.845
KRT85
Keratin, type II cuticular Hb5; Keratin 85; Belongs to the intermediate filament family.
  
 
0.829
KRT81
Keratin, type II cuticular Hb1; Keratin 81.
  
0.825
KRT86
Keratin, type II cuticular Hb6.
  
0.814
KRT71
Keratin, type II cytoskeletal 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle.
  
0.783
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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