Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
GPR45Probable G-protein coupled receptor 45; Orphan receptor. May play a role in brain function. (372 aa)    
Predicted Functional Partners:
GPR20
G-protein coupled receptor 20; Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.
     
 0.635
GPR176
G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist- independent basal activity to repress cAMP production.
     
 0.630
GPR27
Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.
   
 
 0.610
GPR83
Probable G-protein coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor.
   
 
0.567
GPR15
G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; Belongs to the G-protein coupled receptor 1 family.
   
 
0.558
GPR150
Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
   
 
 0.551
GPR25
Probable G-protein coupled receptor 25; Orphan receptor.
   
 
0.545
CCZ1
CCZ1 homolog, vacuolar protein trafficking and biogenesis associated.
    
   0.541
GPR84
G-protein coupled receptor 84; Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system.
   
 
0.521
PYROXD2
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase; Belongs to the carotenoid/retinoid oxidoreductase family.
    
   0.502
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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