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ALPK3 protein (human) - STRING interaction network
"ALPK3" - Alpha-protein kinase 3 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
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[Homology]
Score
ALPK3Alpha-protein kinase 3; Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Plays a role in cardiomyocyte differentiation (By similarity); I-set domain containing (1907 aa)    
Predicted Functional Partners:
EIF2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on ’Ser-52’ during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated [...] (1116 aa)
           
  0.754
PAX4
Paired box protein Pax-4; Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity; PRD class homeoboxes and pseudogenes (343 aa)
           
  0.711
PRSS54
Serine protease 54 (395 aa)
           
  0.672
C1orf167
Uncharacterized protein C1orf167; Chromosome 1 open reading frame 167 (1468 aa)
           
  0.587
ALPK1
Alpha-protein kinase 1; Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (1244 aa)
           
  0.587
OR5C1
Olfactory receptor 5C1; Odorant receptor; Olfactory receptors, family 5 (320 aa)
           
  0.585
WDR25
WD repeat-containing protein 25; WD repeat domain containing (544 aa)
           
  0.579
ZNF592
Zinc finger protein 592; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (1267 aa)
           
  0.555
GPR25
Probable G-protein coupled receptor 25; Orphan receptor; G protein-coupled receptors, Class A orphans (361 aa)
           
  0.514
ABCC6
Multidrug resistance-associated protein 6; Isoform 1- May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS); ATP binding cassette subfamily C (1503 aa)
           
  0.496
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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