STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PSORS1C2Psoriasis susceptibility 1 candidate 2. (136 aa)    
Predicted Functional Partners:
CCHCR1
Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation.
 
    
 0.778
CDSN
Corneodesmosin; Important for the epidermal barrier integrity.
   
  
 0.739
PSORS1C1
Psoriasis susceptibility 1 candidate 1.
   
  
 0.630
C6orf15
Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15.
   
  
 0.545
ALOXE3
Hydroperoxide isomerase ALOXE3; Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty [...]
   
  
 0.537
TCF19
Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.
      
 0.507
GTSF1
Gametocyte-specific factor 1; Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells. Belongs to the UPF0224 (FAM112) family.
      
 0.505
SAPCD1
Suppressor APC domain containing 1.
      
 0.503
VASP
Vasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end [...]
   
   0.489
ITSN2
Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes.
    
 
 0.464
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.