node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACOT11 | FGFBP2 | ENSP00000360366 | ENSP00000259989 | Acyl-coenzyme A thioesterase 11; Has an acyl-CoA thioesterase activity with a preference for the long chain fatty acyl-CoA thioesters hexadecanoyl-CoA/palmitoyl-CoA and tetradecanoyl-CoA/myristoyl-CoA which are the main substrates in the mitochondrial beta-oxidation pathway. | Fibroblast growth factor binding protein 2. | 0.610 |
FGFBP2 | ACOT11 | ENSP00000259989 | ENSP00000360366 | Fibroblast growth factor binding protein 2. | Acyl-coenzyme A thioesterase 11; Has an acyl-CoA thioesterase activity with a preference for the long chain fatty acyl-CoA thioesters hexadecanoyl-CoA/palmitoyl-CoA and tetradecanoyl-CoA/myristoyl-CoA which are the main substrates in the mitochondrial beta-oxidation pathway. | 0.610 |
FGFBP2 | GNLY | ENSP00000259989 | ENSP00000436423 | Fibroblast growth factor binding protein 2. | Granulysin; Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis. | 0.850 |
FGFBP2 | GZMA | ENSP00000259989 | ENSP00000274306 | Fibroblast growth factor binding protein 2. | Granzyme A; Abundant protease in the cytosolic granules of cytotoxic T- cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. Belongs to the peptidase S1 family. Granzym [...] | 0.617 |
FGFBP2 | GZMH | ENSP00000259989 | ENSP00000216338 | Fibroblast growth factor binding protein 2. | Granzyme H; Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication. | 0.905 |
FGFBP2 | GZMK | ENSP00000259989 | ENSP00000231009 | Fibroblast growth factor binding protein 2. | Granzyme K; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.649 |
FGFBP2 | KLRD1 | ENSP00000259989 | ENSP00000338130 | Fibroblast growth factor binding protein 2. | Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. | 0.659 |
FGFBP2 | KLRF1 | ENSP00000259989 | ENSP00000483713 | Fibroblast growth factor binding protein 2. | Killer cell lectin-like receptor subfamily F member 1; Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts. | 0.676 |
FGFBP2 | NKG7 | ENSP00000259989 | ENSP00000221978 | Fibroblast growth factor binding protein 2. | Protein NKG7; Natural killer cell granule protein 7; Belongs to the PMP-22/EMP/MP20 family. | 0.770 |
FGFBP2 | PRF1 | ENSP00000259989 | ENSP00000398568 | Fibroblast growth factor binding protein 2. | Perforin-1; Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. Belongs to the complement C6/C7/C8/C9 family. | 0.622 |
FGFBP2 | S1PR5 | ENSP00000259989 | ENSP00000328472 | Fibroblast growth factor binding protein 2. | Sphingosine 1-phosphate receptor 5; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. | 0.664 |
GNLY | FGFBP2 | ENSP00000436423 | ENSP00000259989 | Granulysin; Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis. | Fibroblast growth factor binding protein 2. | 0.850 |
GNLY | GZMA | ENSP00000436423 | ENSP00000274306 | Granulysin; Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis. | Granzyme A; Abundant protease in the cytosolic granules of cytotoxic T- cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. Belongs to the peptidase S1 family. Granzym [...] | 0.976 |
GNLY | GZMH | ENSP00000436423 | ENSP00000216338 | Granulysin; Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis. | Granzyme H; Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication. | 0.958 |
GNLY | GZMK | ENSP00000436423 | ENSP00000231009 | Granulysin; Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis. | Granzyme K; Belongs to the peptidase S1 family. Granzyme subfamily. | 0.828 |
GNLY | KLRD1 | ENSP00000436423 | ENSP00000338130 | Granulysin; Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis. | Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. | 0.904 |
GNLY | KLRF1 | ENSP00000436423 | ENSP00000483713 | Granulysin; Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis. | Killer cell lectin-like receptor subfamily F member 1; Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts. | 0.744 |
GNLY | NKG7 | ENSP00000436423 | ENSP00000221978 | Granulysin; Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis. | Protein NKG7; Natural killer cell granule protein 7; Belongs to the PMP-22/EMP/MP20 family. | 0.951 |
GNLY | PRF1 | ENSP00000436423 | ENSP00000398568 | Granulysin; Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis. | Perforin-1; Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. Belongs to the complement C6/C7/C8/C9 family. | 0.999 |
GNLY | S1PR5 | ENSP00000436423 | ENSP00000328472 | Granulysin; Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis. | Sphingosine 1-phosphate receptor 5; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. | 0.529 |