node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDHR2 | TMEM62 | ENSP00000424565 | ENSP00000260403 | Cadherin-related family member 2; Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. May also play a role in cell-cell adhesion and contact inhibition in epithelial cells. | Transmembrane protein 62. | 0.404 |
SPRYD4 | TMEM62 | ENSP00000338034 | ENSP00000260403 | SPRY domain containing 4. | Transmembrane protein 62. | 0.429 |
ST8SIA5 | TMEM62 | ENSP00000445492 | ENSP00000260403 | Alpha-2,8-sialyltransferase 8E; May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively. Belongs to the glycosyltransferase 29 family. | Transmembrane protein 62. | 0.483 |
TMEM131L | TMEM62 | ENSP00000386787 | ENSP00000260403 | Transmembrane protein 131-like; [Isoform 1]: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation. | Transmembrane protein 62. | 0.467 |
TMEM132A | TMEM164 | ENSP00000005286 | ENSP00000361138 | Transmembrane protein 132A; May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity); Belongs to the TMEM132 family. | Transmembrane protein 164; Belongs to the TMEM164 family. | 0.415 |
TMEM132A | TMEM62 | ENSP00000005286 | ENSP00000260403 | Transmembrane protein 132A; May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity); Belongs to the TMEM132 family. | Transmembrane protein 62. | 0.511 |
TMEM164 | TMEM132A | ENSP00000361138 | ENSP00000005286 | Transmembrane protein 164; Belongs to the TMEM164 family. | Transmembrane protein 132A; May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity); Belongs to the TMEM132 family. | 0.415 |
TMEM164 | TMEM62 | ENSP00000361138 | ENSP00000260403 | Transmembrane protein 164; Belongs to the TMEM164 family. | Transmembrane protein 62. | 0.488 |
TMEM62 | CDHR2 | ENSP00000260403 | ENSP00000424565 | Transmembrane protein 62. | Cadherin-related family member 2; Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. May also play a role in cell-cell adhesion and contact inhibition in epithelial cells. | 0.404 |
TMEM62 | SPRYD4 | ENSP00000260403 | ENSP00000338034 | Transmembrane protein 62. | SPRY domain containing 4. | 0.429 |
TMEM62 | ST8SIA5 | ENSP00000260403 | ENSP00000445492 | Transmembrane protein 62. | Alpha-2,8-sialyltransferase 8E; May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively. Belongs to the glycosyltransferase 29 family. | 0.483 |
TMEM62 | TMEM131L | ENSP00000260403 | ENSP00000386787 | Transmembrane protein 62. | Transmembrane protein 131-like; [Isoform 1]: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation. | 0.467 |
TMEM62 | TMEM132A | ENSP00000260403 | ENSP00000005286 | Transmembrane protein 62. | Transmembrane protein 132A; May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity); Belongs to the TMEM132 family. | 0.511 |
TMEM62 | TMEM164 | ENSP00000260403 | ENSP00000361138 | Transmembrane protein 62. | Transmembrane protein 164; Belongs to the TMEM164 family. | 0.488 |
TMEM62 | TMEM63C | ENSP00000260403 | ENSP00000298351 | Transmembrane protein 62. | Calcium permeable stress-gated cation channel 1; Acts as an osmosensitive calcium-permeable cation channel. Required for the functional integrity of the kidney glomerular filtration barrier (By similarity). Belongs to the CSC1 (TC 1.A.17) family. | 0.405 |
TMEM63C | TMEM62 | ENSP00000298351 | ENSP00000260403 | Calcium permeable stress-gated cation channel 1; Acts as an osmosensitive calcium-permeable cation channel. Required for the functional integrity of the kidney glomerular filtration barrier (By similarity). Belongs to the CSC1 (TC 1.A.17) family. | Transmembrane protein 62. | 0.405 |