STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCDC54Coiled-coil domain containing 54. (328 aa)    
Predicted Functional Partners:
TMCO2
Transmembrane and coiled-coil domains 2.
   
  
 0.625
C22orf23
UPF0193 protein EVG1; Chromosome 22 open reading frame 23.
   
  
 0.597
C12orf50
Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50.
   
  
 0.563
ADAM29
Disintegrin and metalloproteinase domain-containing protein 29; May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.
   
  
 0.551
C20orf173
Uncharacterized protein C20orf173; Chromosome 20 open reading frame 173.
   
  
 0.549
CCDC187
Coiled-coil domain containing 187.
      
 0.543
CABS1
Calcium-binding and spermatid-specific protein 1; Calcium binding protein, spermatid associated 1.
   
  
 0.525
TNP1
Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. Belongs to the nuclear transition protein 1 family.
   
  
 0.519
FAM71F1
Protein FAM71F1; Family with sequence similarity 71 member F1.
   
  
 0.517
RIMBP3
RIMS-binding protein 3A; Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development; Belongs to the RIMBP family.
      
 0.512
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.