FAM189A1 protein (human) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBA2	FAM189A1	ENSP00000453293	ENSP00000261275	Amyloid-beta A4 precursor protein-binding family A member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.	Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family.	0.410
FAM189A1	APBA2	ENSP00000261275	ENSP00000453293	Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family.	Amyloid-beta A4 precursor protein-binding family A member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.	0.410
FAM189A1	GBX1	ENSP00000261275	ENSP00000297537	Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family.	Homeobox protein GBX-1; Gastrulation brain homeobox 1.	0.461
FAM189A1	IQCA1L	ENSP00000261275	ENSP00000482119	Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family.	IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.	0.550
FAM189A1	N4BP1	ENSP00000261275	ENSP00000262384	Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family.	NEDD4-binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity); Belongs to the N4BP1 family.	0.447
FAM189A1	RNF212	ENSP00000261275	ENSP00000389709	Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family.	Probable E3 SUMO-protein ligase RNF212; SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with [...]	0.449
FAM189A1	TMEM179	ENSP00000261275	ENSP00000450958	Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family.	Transmembrane protein 179; Belongs to the TMEM179 family.	0.401
GBX1	FAM189A1	ENSP00000297537	ENSP00000261275	Homeobox protein GBX-1; Gastrulation brain homeobox 1.	Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family.	0.461
GBX1	IQCA1L	ENSP00000297537	ENSP00000482119	Homeobox protein GBX-1; Gastrulation brain homeobox 1.	IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.	0.565
IQCA1L	FAM189A1	ENSP00000482119	ENSP00000261275	IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.	Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family.	0.550
IQCA1L	GBX1	ENSP00000482119	ENSP00000297537	IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.	Homeobox protein GBX-1; Gastrulation brain homeobox 1.	0.565
IQCA1L	RNF212	ENSP00000482119	ENSP00000389709	IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.	Probable E3 SUMO-protein ligase RNF212; SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with [...]	0.492
N4BP1	FAM189A1	ENSP00000262384	ENSP00000261275	NEDD4-binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity); Belongs to the N4BP1 family.	Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family.	0.447
RNF212	FAM189A1	ENSP00000389709	ENSP00000261275	Probable E3 SUMO-protein ligase RNF212; SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with [...]	Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family.	0.449
RNF212	IQCA1L	ENSP00000389709	ENSP00000482119	Probable E3 SUMO-protein ligase RNF212; SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with [...]	IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.	0.492
TMEM179	FAM189A1	ENSP00000450958	ENSP00000261275	Transmembrane protein 179; Belongs to the TMEM179 family.	Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family.	0.401