STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FAM189A1Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family. (539 aa)    
Predicted Functional Partners:
IQCA1L
IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.
      
 0.605
TMEM88B
Transmembrane protein 88B.
   
  
 0.488
TMEM179
Transmembrane protein 179; Belongs to the TMEM179 family.
   
  
 0.478
APBA2
Amyloid-beta A4 precursor protein-binding family A member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.
   
  
 0.474
TMEM145
Transmembrane protein 145.
   
  
 0.460
STUM
Protein stum homolog; Stum, mechanosensory transduction mediator homolog.
   
  
 0.454
FAM81A
Protein FAM81A; Family with sequence similarity 81 member A; Belongs to the FAM81 family.
   
  
 0.451
FAM171B
Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family.
   
  
 0.449
TMEM59L
Transmembrane protein 59-like; Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.
   
 
 0.436
AMER3
APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity).
   
  
 0.434
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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