node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALAD | EPB41L4A | ENSP00000386284 | ENSP00000482810 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen; Belongs to the ALAD family. | Erythrocyte membrane protein band 4.1 like 4A. | 0.451 |
ARHGEF37 | EPB41L4A | ENSP00000328083 | ENSP00000482810 | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | Erythrocyte membrane protein band 4.1 like 4A. | 0.424 |
CCT5 | EPB41L4A | ENSP00000280326 | ENSP00000482810 | T-complex protein 1 subunit epsilon; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin (Probable). | Erythrocyte membrane protein band 4.1 like 4A. | 0.429 |
CTNNB1 | EPB41L4A | ENSP00000495360 | ENSP00000482810 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | Erythrocyte membrane protein band 4.1 like 4A. | 0.409 |
DYNLL2 | EPB41L4A | ENSP00000477310 | ENSP00000482810 | Dynein light chain 2, cytoplasmic; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity); Belongs to the dynein light chain family. | Erythrocyte membrane protein band 4.1 like 4A. | 0.465 |
EPB41L4A | ALAD | ENSP00000482810 | ENSP00000386284 | Erythrocyte membrane protein band 4.1 like 4A. | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen; Belongs to the ALAD family. | 0.451 |
EPB41L4A | ARHGEF37 | ENSP00000482810 | ENSP00000328083 | Erythrocyte membrane protein band 4.1 like 4A. | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | 0.424 |
EPB41L4A | CCT5 | ENSP00000482810 | ENSP00000280326 | Erythrocyte membrane protein band 4.1 like 4A. | T-complex protein 1 subunit epsilon; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin (Probable). | 0.429 |
EPB41L4A | CTNNB1 | ENSP00000482810 | ENSP00000495360 | Erythrocyte membrane protein band 4.1 like 4A. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | 0.409 |
EPB41L4A | DYNLL2 | ENSP00000482810 | ENSP00000477310 | Erythrocyte membrane protein band 4.1 like 4A. | Dynein light chain 2, cytoplasmic; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity); Belongs to the dynein light chain family. | 0.465 |
EPB41L4A | KIAA1755 | ENSP00000482810 | ENSP00000279024 | Erythrocyte membrane protein band 4.1 like 4A. | Uncharacterized protein KIAA1755; KIAA1755. | 0.460 |
EPB41L4A | MAB21L3 | ENSP00000482810 | ENSP00000358512 | Erythrocyte membrane protein band 4.1 like 4A. | Protein mab-21-like 3; Mab-21 like 3. | 0.428 |
EPB41L4A | PCNX2 | ENSP00000482810 | ENSP00000258229 | Erythrocyte membrane protein band 4.1 like 4A. | Pecanex-like protein 2; May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H). Belongs to the pecanex family. | 0.494 |
EPB41L4A | SLC6A7 | ENSP00000482810 | ENSP00000230671 | Erythrocyte membrane protein band 4.1 like 4A. | Sodium-dependent proline transporter; Terminates the action of proline by its high affinity sodium- dependent reuptake into presynaptic terminals. | 0.414 |
EPB41L4A | TAAR1 | ENSP00000482810 | ENSP00000275216 | Erythrocyte membrane protein band 4.1 like 4A. | Trace amine-associated receptor 1; Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained spe [...] | 0.813 |
KIAA1755 | EPB41L4A | ENSP00000279024 | ENSP00000482810 | Uncharacterized protein KIAA1755; KIAA1755. | Erythrocyte membrane protein band 4.1 like 4A. | 0.460 |
KIAA1755 | SLC6A7 | ENSP00000279024 | ENSP00000230671 | Uncharacterized protein KIAA1755; KIAA1755. | Sodium-dependent proline transporter; Terminates the action of proline by its high affinity sodium- dependent reuptake into presynaptic terminals. | 0.480 |
MAB21L3 | EPB41L4A | ENSP00000358512 | ENSP00000482810 | Protein mab-21-like 3; Mab-21 like 3. | Erythrocyte membrane protein band 4.1 like 4A. | 0.428 |
PCNX2 | EPB41L4A | ENSP00000258229 | ENSP00000482810 | Pecanex-like protein 2; May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H). Belongs to the pecanex family. | Erythrocyte membrane protein band 4.1 like 4A. | 0.494 |
SLC6A7 | EPB41L4A | ENSP00000230671 | ENSP00000482810 | Sodium-dependent proline transporter; Terminates the action of proline by its high affinity sodium- dependent reuptake into presynaptic terminals. | Erythrocyte membrane protein band 4.1 like 4A. | 0.414 |