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VPS13C protein (human) - STRING interaction network
"VPS13C" - Vacuolar protein sorting-associated protein 13C in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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VPS13CVacuolar protein sorting-associated protein 13C; Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (3753 aa)    
Predicted Functional Partners:
LGALS12
Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes; Galectins (337 aa)
       
 
  0.847
CCDC129
Coiled-coil domain containing 129 (1062 aa)
           
  0.761
SIPA1L2
Signal-induced proliferation-associated 1-like protein 2; Signal induced proliferation associated 1 like 2; PDZ domain containing (1722 aa)
           
  0.672
VPS35
Vacuolar protein sorting-associated protein 35; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may [...] (796 aa)
     
 
  0.645
ZDHHC21
Palmitoyltransferase ZDHHC21; Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity); Belongs to the DHHC palmitoyltransferase family (265 aa)
     
   
  0.626
SNX19
Sorting nexin-19; Plays a role in intracellular vesicle trafficking and exocytosis. May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity); Belongs to the sorting nexin family (992 aa)
           
  0.608
NOL4L
Nucleolar protein 4 like (680 aa)
           
  0.607
TXLNG
Gamma-taxilin; May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression (528 aa)
           
  0.605
C2CD4B
C2 calcium-dependent domain-containing protein 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion; Belongs to the C2CD4 family (364 aa)
           
  0.599
MYO9A
Unconventional myosin-IXa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho activity in neurons, has a role in the regulation of neuronal morphology and function (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (2548 aa)
     
 
  0.596
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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