ERICH1 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ERICH1	ERICH6	ENSP00000262109	ENSP00000295910	Glutamate-rich protein 1; Glutamate rich 1.	Glutamate-rich protein 6; Glutamate rich 6.	0.500
ERICH1	FBXO25	ENSP00000262109	ENSP00000372274	Glutamate-rich protein 1; Glutamate rich 1.	F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).	0.489
ERICH1	MTG1	ENSP00000262109	ENSP00000323047	Glutamate-rich protein 1; Glutamate rich 1.	Mitochondrial ribosome-associated GTPase 1; Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.	0.500
ERICH1	PAGR1	ENSP00000262109	ENSP00000326519	Glutamate-rich protein 1; Glutamate rich 1.	PAXIP1-associated glutamate-rich protein 1; Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switchin [...]	0.522
ERICH1	RSBN1L	ENSP00000262109	ENSP00000334040	Glutamate-rich protein 1; Glutamate rich 1.	Lysine-specific demethylase RSBN1L; Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins; Belongs to the round spermatid basic protein 1 family.	0.459
ERICH1	TDRP	ENSP00000262109	ENSP00000430325	Glutamate-rich protein 1; Glutamate rich 1.	Testis development-related protein; Contributes to normal sperm motility, but not essential for male fertility; Belongs to the TDRP family.	0.479
ERICH1	TMEM131	ENSP00000262109	ENSP00000186436	Glutamate-rich protein 1; Glutamate rich 1.	Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family.	0.486
ERICH1	TTC9B	ENSP00000262109	ENSP00000311760	Glutamate-rich protein 1; Glutamate rich 1.	Tetratricopeptide repeat domain 9B; Belongs to the TTC9 family.	0.477
ERICH1	ZNF596	ENSP00000262109	ENSP00000381613	Glutamate-rich protein 1; Glutamate rich 1.	Zinc finger protein 596; May be involved in transcriptional regulation.	0.498
ERICH1	ZRANB1	ENSP00000262109	ENSP00000352676	Glutamate-rich protein 1; Glutamate rich 1.	Ubiquitin thioesterase ZRANB1; Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling; Belongs to the peptidase C64 family.	0.457
ERICH6	ERICH1	ENSP00000295910	ENSP00000262109	Glutamate-rich protein 6; Glutamate rich 6.	Glutamate-rich protein 1; Glutamate rich 1.	0.500
FBXO25	ERICH1	ENSP00000372274	ENSP00000262109	F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).	Glutamate-rich protein 1; Glutamate rich 1.	0.489
FBXO25	TDRP	ENSP00000372274	ENSP00000430325	F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).	Testis development-related protein; Contributes to normal sperm motility, but not essential for male fertility; Belongs to the TDRP family.	0.611
FBXO25	ZNF596	ENSP00000372274	ENSP00000381613	F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).	Zinc finger protein 596; May be involved in transcriptional regulation.	0.513
MTG1	ERICH1	ENSP00000323047	ENSP00000262109	Mitochondrial ribosome-associated GTPase 1; Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.	Glutamate-rich protein 1; Glutamate rich 1.	0.500
MTG1	ZRANB1	ENSP00000323047	ENSP00000352676	Mitochondrial ribosome-associated GTPase 1; Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.	Ubiquitin thioesterase ZRANB1; Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling; Belongs to the peptidase C64 family.	0.457
PAGR1	ERICH1	ENSP00000326519	ENSP00000262109	PAXIP1-associated glutamate-rich protein 1; Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switchin [...]	Glutamate-rich protein 1; Glutamate rich 1.	0.522
RSBN1L	ERICH1	ENSP00000334040	ENSP00000262109	Lysine-specific demethylase RSBN1L; Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins; Belongs to the round spermatid basic protein 1 family.	Glutamate-rich protein 1; Glutamate rich 1.	0.459
RSBN1L	ZRANB1	ENSP00000334040	ENSP00000352676	Lysine-specific demethylase RSBN1L; Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins; Belongs to the round spermatid basic protein 1 family.	Ubiquitin thioesterase ZRANB1; Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling; Belongs to the peptidase C64 family.	0.463
TDRP	ERICH1	ENSP00000430325	ENSP00000262109	Testis development-related protein; Contributes to normal sperm motility, but not essential for male fertility; Belongs to the TDRP family.	Glutamate-rich protein 1; Glutamate rich 1.	0.479