node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD13D | CRISPLD2 | ENSP00000427130 | ENSP00000262424 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | 0.525 |
ARSB | CRISPLD2 | ENSP00000264914 | ENSP00000262424 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | 0.599 |
BCL3 | CRISPLD2 | ENSP00000164227 | ENSP00000262424 | B-cell lymphoma 3 protein; Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity); Ankyrin repeat domain containing | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | 0.508 |
CRISPLD2 | ANKRD13D | ENSP00000262424 | ENSP00000427130 | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | 0.525 |
CRISPLD2 | ARSB | ENSP00000262424 | ENSP00000264914 | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | 0.599 |
CRISPLD2 | BCL3 | ENSP00000262424 | ENSP00000164227 | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | B-cell lymphoma 3 protein; Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity); Ankyrin repeat domain containing | 0.508 |
CRISPLD2 | DNHD1 | ENSP00000262424 | ENSP00000254579 | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | Dynein heavy chain domain-containing protein 1; Dynein heavy chain domain 1 | 0.661 |
CRISPLD2 | FAM92B | ENSP00000262424 | ENSP00000443411 | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | Family with sequence similarity 92 member b; Protein FAM92B; May play a role in ciliogenesis (By similarity). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis | 0.621 |
CRISPLD2 | HHIPL2 | ENSP00000262424 | ENSP00000342118 | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family | 0.512 |
CRISPLD2 | IRF6 | ENSP00000262424 | ENSP00000355988 | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | Interferon regulatory factor 6; Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity); Belongs to the IRF family | 0.527 |
CRISPLD2 | TBX10 | ENSP00000262424 | ENSP00000335191 | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | T-box transcription factor TBX10; Probable transcriptional regulator involved in developmental processes; T-boxes | 0.523 |
CRISPLD2 | YOD1 | ENSP00000262424 | ENSP00000326813 | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. A [...] | 0.567 |
CRISPLD2 | ZDHHC7 | ENSP00000262424 | ENSP00000456782 | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | Palmitoyltransferase; Zinc finger DHHC-type containing 7; Belongs to the DHHC palmitoyltransferase family | 0.623 |
DNHD1 | CRISPLD2 | ENSP00000254579 | ENSP00000262424 | Dynein heavy chain domain-containing protein 1; Dynein heavy chain domain 1 | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | 0.661 |
FAM92B | CRISPLD2 | ENSP00000443411 | ENSP00000262424 | Family with sequence similarity 92 member b; Protein FAM92B; May play a role in ciliogenesis (By similarity). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | 0.621 |
FAM92B | ZDHHC7 | ENSP00000443411 | ENSP00000456782 | Family with sequence similarity 92 member b; Protein FAM92B; May play a role in ciliogenesis (By similarity). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis | Palmitoyltransferase; Zinc finger DHHC-type containing 7; Belongs to the DHHC palmitoyltransferase family | 0.727 |
HHIPL2 | CRISPLD2 | ENSP00000342118 | ENSP00000262424 | HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | 0.512 |
IRF6 | CRISPLD2 | ENSP00000355988 | ENSP00000262424 | Interferon regulatory factor 6; Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity); Belongs to the IRF family | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | 0.527 |
IRF6 | TBX10 | ENSP00000355988 | ENSP00000335191 | Interferon regulatory factor 6; Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity); Belongs to the IRF family | T-box transcription factor TBX10; Probable transcriptional regulator involved in developmental processes; T-boxes | 0.509 |
TBX10 | CRISPLD2 | ENSP00000335191 | ENSP00000262424 | T-box transcription factor TBX10; Probable transcriptional regulator involved in developmental processes; T-boxes | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | 0.523 |