DZANK1 protein (human) - STRING interaction network

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gene neighborhood

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Score

DZANK1

Double zinc ribbon and ankyrin repeat domains 1. (752 aa)

Predicted Functional Partners:

RBBP9

0.533

ZNF133

0.514

NINL

0.492

OVOL2

0.483

TROAP

0.475

RNFT2

0.471

TMEM88B

0.470

CEP128

0.445

CC2D2A

0.439

POLR3F

0.424

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CC2D2A	DZANK1	ENSP00000403465	ENSP00000262547	Coiled-coil and C2 domain-containing protein 2A; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).	Double zinc ribbon and ankyrin repeat domains 1.	0.439
CC2D2A	NINL	ENSP00000403465	ENSP00000278886	Coiled-coil and C2 domain-containing protein 2A; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).	Ninein-like protein; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis.	0.562
CEP128	DZANK1	ENSP00000451162	ENSP00000262547	Centrosomal protein 128.	Double zinc ribbon and ankyrin repeat domains 1.	0.445
DZANK1	CC2D2A	ENSP00000262547	ENSP00000403465	Double zinc ribbon and ankyrin repeat domains 1.	Coiled-coil and C2 domain-containing protein 2A; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).	0.439
DZANK1	CEP128	ENSP00000262547	ENSP00000451162	Double zinc ribbon and ankyrin repeat domains 1.	Centrosomal protein 128.	0.445
DZANK1	NINL	ENSP00000262547	ENSP00000278886	Double zinc ribbon and ankyrin repeat domains 1.	Ninein-like protein; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis.	0.492
DZANK1	OVOL2	ENSP00000262547	ENSP00000278780	Double zinc ribbon and ankyrin repeat domains 1.	Transcription factor Ovo-like 2; Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. Important for the correct development of primordial germ cells in embryos (By similarity).	0.483
DZANK1	POLR3F	ENSP00000262547	ENSP00000366828	Double zinc ribbon and ankyrin repeat domains 1.	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRN [...]	0.424
DZANK1	RBBP9	ENSP00000262547	ENSP00000336866	Double zinc ribbon and ankyrin repeat domains 1.	Serine hydrolase RBBP9; Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1.	0.533
DZANK1	RNFT2	ENSP00000262547	ENSP00000257575	Double zinc ribbon and ankyrin repeat domains 1.	Ring finger protein, transmembrane 2.	0.471
DZANK1	TMEM88B	ENSP00000262547	ENSP00000455099	Double zinc ribbon and ankyrin repeat domains 1.	Transmembrane protein 88B.	0.470
DZANK1	TROAP	ENSP00000262547	ENSP00000257909	Double zinc ribbon and ankyrin repeat domains 1.	Tastin; Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation.	0.475
DZANK1	ZNF133	ENSP00000262547	ENSP00000439427	Double zinc ribbon and ankyrin repeat domains 1.	Zinc finger protein 133; May be involved in transcriptional regulation as a repressor.	0.514
NINL	CC2D2A	ENSP00000278886	ENSP00000403465	Ninein-like protein; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis.	Coiled-coil and C2 domain-containing protein 2A; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).	0.562
NINL	DZANK1	ENSP00000278886	ENSP00000262547	Ninein-like protein; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis.	Double zinc ribbon and ankyrin repeat domains 1.	0.492
OVOL2	DZANK1	ENSP00000278780	ENSP00000262547	Transcription factor Ovo-like 2; Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. Important for the correct development of primordial germ cells in embryos (By similarity).	Double zinc ribbon and ankyrin repeat domains 1.	0.483
POLR3F	DZANK1	ENSP00000366828	ENSP00000262547	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRN [...]	Double zinc ribbon and ankyrin repeat domains 1.	0.424
POLR3F	RBBP9	ENSP00000366828	ENSP00000336866	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRN [...]	Serine hydrolase RBBP9; Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1.	0.486
POLR3F	ZNF133	ENSP00000366828	ENSP00000439427	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRN [...]	Zinc finger protein 133; May be involved in transcriptional regulation as a repressor.	0.526
RBBP9	DZANK1	ENSP00000336866	ENSP00000262547	Serine hydrolase RBBP9; Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1.	Double zinc ribbon and ankyrin repeat domains 1.	0.533