STRINGSTRING
CNPY4 protein (human) - STRING interaction network
"CNPY4" - Canopy 4 homolog in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
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CNPY4Canopy 4 homolog (zebrafish); Plays a role in the regulation of the cell surface expression of TLR4 (248 aa)    
Predicted Functional Partners:
LY96
Lymphocyte antigen 96; Binds bacterial lipopolysaccharide (LPS) (PubMed-17803912, PubMed-17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram- positive and Gram-negative bacteria (PubMed-11160242, PubMed-11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed-10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed-10359581) (160 aa)
           
  0.721
TLR4
Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed-9237759, PubMed-10835634). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Responses triggered by Ni(2+) require non-conserved histidines and are, therefore, species-specific (PubMed-20711192). In complex with TLR6, promotes sterile inflammation in monocytes/macrophage [...] (839 aa)
       
 
  0.684
CHAD
Chondroadherin; Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity) (359 aa)
       
      0.441
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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